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Cat. No.: HY-172160

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HER2-IN-21

HER2-IN-21 (compound 657994) is a human epidermal growth factor receptor 2 (HER2) inhibitor, with an IC₅₀ of 3.85 μM.

For research use only. We do not sell to patients.

CAS No.: 906437-59-0
Formula: C₂₀H₁₈N₄O₃S
Molecular Weight:394.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

HER2-IN-21 Chemical Structure

CAS No.: 906437-59-0

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity

Description

HER2-IN-21 (compound 657994) is a human epidermal growth factor receptor 2 (HER2) inhibitor, with an IC₅₀ of 3.85 μM^[1].

All EGFR Isoforms :

Chemical Information

CAS No. 906437-59-0
Molecular Weight 394.45
Formula C₂₀H₁₈N₄O₃S
SMILES

COC1=CC=CC(C2SC(N)=NC3=C2C(C)=NN3C(C4=CC=CC=C4O)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Matrouk AY, et al. Discovery of New HER2 Inhibitors via Computational Docking, Pharmacophore Modeling, and Machine Learning. Mol Inform. 2025 Feb;44(2):e202400336. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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HER2-IN-21

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HER2-IN-21 Related Classifications

HY-172160 Related Classifications