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Cat. No.: HY-176565

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ZN148

Name: ZN148
Brand: MedChemExpress
SKU: HY-176565
Price: 365.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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ZN148 is a zinc-chelating synthetic metallo-β-lactamase (MBL) inhibitor which attenuates MBL-mediated carbapenem resistance. ZN148 can restore the in vitro clinical susceptibility to carbapenems in >98% of a large international collection of MBL-producing clinical Enterobacterales strains. ZN148 can be utilized in research on anti MBL-producing bacteria.

For research use only. We do not sell to patients.

CAS No.: 2190527-04-7
Formula: C₂₆H₃₃N₅O₆
Molecular Weight:511.57

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

ZN148 Chemical Structure

CAS No.: 2190527-04-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Beta-lactamase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	>100 μM Compound: S29	Cytotoxicity against human HepG2 cells incubated for 24 hrs by AlamarBlue-based assay Cytotoxicity against human HepG2 cells incubated for 24 hrs by AlamarBlue-based assay	[PMID: 37360393]

Chemical Information

CAS No. 2190527-04-7
Appearance Solid
Molecular Weight 511.57
Formula C₂₆H₃₃N₅O₆
Color White to yellow
SMILES

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)CN(C)C(C(C=N1)=CC=C1CN(CC2=CC=CC=N2)CC3=CC=CC=N3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Samuelsen Ø, et al. ZN148 Is a Modular Synthetic Metallo-β-Lactamase Inhibitor That Reverses Carbapenem Resistance in Gram-Negative Pathogens In Vivo. Antimicrob Agents Chemother. 2020 May 21;64(6):e02415-19. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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