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Cat. No.: HY-139871

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hTrkA-IN-2

hTrkA-IN-2 is a selective hTrkA allosteric inhibitor with an IC₅₀ value of 3.9 nM.

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CAS No.: 2986533-14-4
Formule: C₂₄H₂₂F₃N₅O₃
Masse moléculaire:485.46

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

hTrkA-IN-2 Chemical Structure

CAS No.: 2986533-14-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

hTrkA-IN-2 is a selective hTrkA allosteric inhibitor with an IC₅₀ value of 3.9 nM.

Voir tous les produits spécifiques à Isoform Trk Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
PC-12	IC₅₀	329.4 nM Compound: 1	Inhibition of beta-NGF induced neurite outgrowth in rat PC-12 cells preincubated for 30 mins followed by beta-NGF stimulation and incubated for 7 days by IncuCyte zoom live-cell imaging analysis Inhibition of beta-NGF induced neurite outgrowth in rat PC-12 cells preincubated for 30 mins followed by beta-NGF stimulation and incubated for 7 days by IncuCyte zoom live-cell imaging analysis	[PMID: 34795875]

Chemical Information

CAS No. 2986533-14-4
Masse moléculaire 485.46
Formule C₂₄H₂₂F₃N₅O₃
SMILES

O=C(NC1=C(C2=CC=CC=C2)N=C3N1C=CN=C3C)NCC4=C(OC(F)(F)F)C=CC(COC)=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Subramanian G, et al. In Pursuit of an Allosteric Human Tropomyosin Kinase A (hTrkA) Inhibitor for Chronic Pain. ACS Med Chem Lett. 2021 Oct 25;12(11):1847-1852. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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