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Cat. No.: HY-139871

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hTrkA-IN-2

hTrkA-IN-2 is a selective hTrkA allosteric inhibitor with an IC₅₀ value of 3.9 nM.

For research use only. We do not sell to patients.

CAS No.: 2986533-14-4
Formula: C₂₄H₂₂F₃N₅O₃
Molecular Weight:485.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

hTrkA-IN-2 Chemical Structure

CAS No.: 2986533-14-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

hTrkA-IN-2 is a selective hTrkA allosteric inhibitor with an IC₅₀ value of 3.9 nM.

All Trk Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
PC-12	IC₅₀	329.4 nM Compound: 1	Inhibition of beta-NGF induced neurite outgrowth in rat PC-12 cells preincubated for 30 mins followed by beta-NGF stimulation and incubated for 7 days by IncuCyte zoom live-cell imaging analysis Inhibition of beta-NGF induced neurite outgrowth in rat PC-12 cells preincubated for 30 mins followed by beta-NGF stimulation and incubated for 7 days by IncuCyte zoom live-cell imaging analysis	[PMID: 34795875]

Chemical Information

CAS No. 2986533-14-4
Molecular Weight 485.46
Formula C₂₄H₂₂F₃N₅O₃
SMILES

O=C(NC1=C(C2=CC=CC=C2)N=C3N1C=CN=C3C)NCC4=C(OC(F)(F)F)C=CC(COC)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Subramanian G, et al. In Pursuit of an Allosteric Human Tropomyosin Kinase A (hTrkA) Inhibitor for Chronic Pain. ACS Med Chem Lett. 2021 Oct 25;12(11):1847-1852. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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hTrkA-IN-2

All Trk Receptor Isoforms