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Cat. No.: HY-147784

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HZ-A-005

HZ-A-005 is a potent, selective, and covalent Bruton’s tyrosine kinase (BTK) inhibitor. HZ-A-005 markedly decreases tumor growth in xenograft mouse models.

For research use only. We do not sell to patients.

CAS No.: 2041789-14-2
Formula: C₂₅H₂₃ClN₆O₂
Molecular Weight:474.94

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

HZ-A-005 Chemical Structure

CAS No.: 2041789-14-2

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Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

HZ-A-005 is a potent, selective, and covalent Bruton’s tyrosine kinase (BTK) inhibitor. HZ-A-005 markedly decreases tumor growth in xenograft mouse models^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
DOHH-2	IC₅₀	0.22 μM Compound: 42	Antiproliferative activity against human DOHH-2 cells assessed as inhibition of cell proliferation by MTT assay Antiproliferative activity against human DOHH-2 cells assessed as inhibition of cell proliferation by MTT assay	[PMID: 33740548]
HEK293	IC₅₀	5.46 μM Compound: 42	Antiproliferative activity against human HEK293 cells assessed as reduction in cell viability by MTT assay Antiproliferative activity against human HEK293 cells assessed as reduction in cell viability by MTT assay	[PMID: 33740548]
L02	IC₅₀	15.93 μM Compound: 42	Antiproliferative activity against human L02 cells assessed as reduction in cell viability by MTT assay Antiproliferative activity against human L02 cells assessed as reduction in cell viability by MTT assay	[PMID: 33740548]
OCI-Ly10	IC₅₀	0.16 μM Compound: 42	Antiproliferative activity against human OCILY10 cells assessed as inhibition of cell proliferation by MTT assay Antiproliferative activity against human OCILY10 cells assessed as inhibition of cell proliferation by MTT assay	[PMID: 33740548]
Rec1	IC₅₀	0.01 μM Compound: 42	Antiproliferative activity against human REC1 cells assessed as inhibition of cell proliferation by MTT assay Antiproliferative activity against human REC1 cells assessed as inhibition of cell proliferation by MTT assay	[PMID: 33740548]

Chemical Information

CAS No. 2041789-14-2
Molecular Weight 474.94
Formula C₂₅H₂₃ClN₆O₂
SMILES

C=C(C(N1CCC[C@@H](C1)N2N=C(C3=C(N=CN=C32)N)C4=CC=C(C=C4)OC5=CC=CC=C5)=O)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Huang W, et al. HZ-A-005, a potent, selective, and covalent Bruton's tyrosine kinase inhibitor in preclinical development. Bioorg Chem. 2020;105:104377. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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