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Cat. No.: HY-117124

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BMS-337197

BMS-337197 is an inosine monophosphate dehydrogenase (IMPDH) inhibitor.

For research use only. We do not sell to patients.

CAS No.: 267645-83-0
Formula: C₂₆H₂₇N₅O₅
Molecular Weight:489.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

BMS-337197 Chemical Structure

CAS No.: 267645-83-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

BMS-337197 is an inosine monophosphate dehydrogenase (IMPDH) inhibitor^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	IC₅₀	0.52 μM Compound: 30a	Inhibition of CEM cell proliferation. Inhibition of CEM cell proliferation.	[PMID: 12781195]
CCRF-CEM	IC₅₀	0.59 μM Compound: 23	In vitro secondary T-cell (CEM) proliferation assay In vitro secondary T-cell (CEM) proliferation assay	[PMID: 12014950]
CCRF-CEM	IC₅₀	520 nM Compound: BMS-337197	Inhibition of CEM (human leukemia) cell proliferation. Inhibition of CEM (human leukemia) cell proliferation.	[PMID: 14505670]
CCRF-CEM	IC₅₀	590 nM Compound: BMS-337197	Inhibitory concentration against T-cell proliferation response in a CEM cell line (BMS-337197,CEM) Inhibitory concentration against T-cell proliferation response in a CEM cell line (BMS-337197,CEM)	[PMID: 12392738]

In Vitro

BMS-337197 is an inhibitor of inosine monophosphate dehydrogenase (IMPDH)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 267645-83-0
Molecular Weight 489.52
Formula C₂₆H₂₇N₅O₅
SMILES

O=C(N(C1=CC=CC=C1C2=CN=C(NC3=CC=C(C4=CN=CO4)C(OC)=C3)O2)C)CN5CCOCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dhar TG, et al. A modified approach to 2-(N-aryl)-1,3-oxazoles: application to the synthesis of the IMPDH inhibitor BMS-337197 and analogues. Org Lett. 2002;4(12):2091-2093. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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