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Cat. No.: HY-149713

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J1-1

J1-1 is an inhibitor of ICMT with an IC₅₀ of 1.0 μM and has anticancer activity.

For research use only. We do not sell to patients.

CAS No.: 1244769-10-5
Formula: C₂₅H₃₂N₂O
Molecular Weight:376.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

J1-1 Chemical Structure

CAS No.: 1244769-10-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

J1-1 is an inhibitor of ICMT with an IC₅₀ of 1.0 μM and has anticancer activity^[1].

IC₅₀ & Target

IC50: 1.0 μM (ICMT)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	IC₅₀	21.2 μM Compound: 1-2	Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by colorimetric tetrazolium assay Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by colorimetric tetrazolium assay	[PMID: 20809634]
Sf9	IC₅₀	1 μM Compound: 1-2	Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting Inhibition of recombinant ICMT expressed in Sf9 cells using [3H] AdoMet after 20 mins by scintillation counting	[PMID: 20809634]

Chemical Information

CAS No. 1244769-10-5
Molecular Weight 376.53
Formula C₂₅H₃₂N₂O
SMILES

O=C(N)CC1=CN(CCCCCCCC)C2=C1C=C(C3=CC=CC=C3C)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang WS et al. Isoprenyl carboxyl methyltransferase inhibitors: a brief review including recent patents. Amino Acids. 2017 Sep;49(9):1469-1485. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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