NMB-1
NMB-1 is a conopeptide analogue. NMB-1 selectively inhibits sustained mechanically activated currents in sensory neurons (IC50: 1 μM). NMB-1 inhibits mechanical pain. NMB-1 can be used for research of hearing and pressure-evoked pain.
For research use only. We do not sell to patients.
- CAS No.: 2843557-76-4
- Formula: C111H164N36O21S4
- Molecular Weight:2466.98
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 2843557-76-4
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Molecular Weight 2466.98
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Formula C111H164N36O21S4
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Sequence
Phe-Asn-Trp-Arg-Cys-Cys-Leu-Ile-Pro-Cys-Arg-Arg-Asn-His-Lys-Lys-Phe-Phe-Cys-NH2 (Disulfide bridge: Cys5-Cys19, Cys6-Cys10)
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Sequence Shortening
FNWRCCLIPCRRNHKKFFC-NH2 (Disulfide bridge: Cys5-Cys19, Cys6-Cys10)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Drew LJ, et al. High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. PLoS One. 2007 Jun 13;2(6):e515. [Content Brief]
[2]. Raouf R, et al. Inhibition of somatosensory mechanotransduction by annexin A6. Sci Signal. 2018 Jun 19;11(535):eaao2060. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NMB-1 Related Classifications
HY-P5163 Related Classifications
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