IKKβ-IN-3
IKKβ-IN-3 (Compound hit4) is a IKKβ inhibitor with an IC50 value of 30.4 nM. IKKβ is a key enzyme in the NF-κB signaling pathway and is involved in the development of many diseases. IKKβ-IN-3 can be used in the study of CAF-induced arthritis.
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- Formule: C18H27NO4
- Masse moléculaire:321.41
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
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IKKβ 30.4 nM (IC50) |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adjuvant-induced arthritis (AIA) rat model[1]
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Dosage:10 and 30 mg/kg
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Administration:gastric gavage (i.g.)
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Result:At 30 mg/kg, significantly reduced rat paw swelling, inflammatory cell infiltration and hyperemia of the synovium.
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Animal Model:
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Dosage:
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Administration:
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Result:
Chemical Information
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Masse moléculaire 321.41
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Formule C18H27NO4
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SMILES
CC(C[C@H](NC(C[C@H](CC(CC1=CC=CC=C1)=O)O)=O)CO)C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IKKβ-IN-3 Related Classifications
HY-163412 Related Classifications
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