IL-1β-IN-1
Based on 1 Customer Validation
IL-1β-IN-1, cannabidiol derivative, is a potent IL-1β inhibitor. IL-1β-IN-1 has anti-inflammatory and pain-resolving properties.
For research use only. We do not sell to patients.
- Purity: 99.45%
- CAS No.: 2780364-50-1
- Formula: C22H34O2
- Molecular Weight:330.50
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-1β |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:female Sabra mice, 7-8 weeks old[1]
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Dosage:10 and 25 mg/kg
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Administration:intraperitoneal injection
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Result:Reduced swelling and pain sensation.
Reduced plasma TNFα and IL-1β.
Chemical Information
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CAS No. 2780364-50-1
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Appearance Oil
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Molecular Weight 330.50
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Formula C22H34O2
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Color Light yellow to yellow
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SMILES
OC1=C(C(CCCCC)=CC(O)=C1[C@@H]2C=C(CC[C@H]2C(C)C)C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (151.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.0257 mL | 15.1286 mL | 30.2572 mL | 75.6430 mL |
| 5 mM | 0.6051 mL | 3.0257 mL | 6.0514 mL | 15.1286 mL | |
| 10 mM | 0.3026 mL | 1.5129 mL | 3.0257 mL | 7.5643 mL | |
| 15 mM | 0.2017 mL | 1.0086 mL | 2.0171 mL | 5.0429 mL | |
| 20 mM | 0.1513 mL | 0.7564 mL | 1.5129 mL | 3.7821 mL | |
| 25 mM | 0.1210 mL | 0.6051 mL | 1.2103 mL | 3.0257 mL | |
| 30 mM | 0.1009 mL | 0.5043 mL | 1.0086 mL | 2.5214 mL | |
| 40 mM | 0.0756 mL | 0.3782 mL | 0.7564 mL | 1.8911 mL | |
| 50 mM | 0.0605 mL | 0.3026 mL | 0.6051 mL | 1.5129 mL | |
| 60 mM | 0.0504 mL | 0.2521 mL | 0.5043 mL | 1.2607 mL | |
| 80 mM | 0.0378 mL | 0.1891 mL | 0.3782 mL | 0.9455 mL | |
| 100 mM | 0.0303 mL | 0.1513 mL | 0.3026 mL | 0.7564 mL |
IL-1β-IN-1 Related Classifications
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