Imiloxan hydrochloride
Based on 1 Customer Validation
Imiloxan (RS 21361) hydrochloride is a potent and selective alpha 2B-adrenoceptor antagonist. Imiloxan hydrochloride produces a dose-related reversal of Guanoxabenz (HY-U00123)-induced maximal mydriasis in male rats. Imiloxan hydrochloride has the potential for acute kidney injury research.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit : 98.47%
- CAS. Nr.: 81167-22-8
- Formel: C14H17ClN2O2
- Molecular Weight:280.75
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Speicherung:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Beschreibung
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
>10 μM
Compound: GNF-Pf-2156
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NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
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[PMID: 18579783] |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 81167-22-8
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Appearance Solid
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Molecular Weight 280.75
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Formel C14H17ClN2O2
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Color White to light yellow
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SMILES
CCN1C=CN=C1CC2OC3=CC=CC=C3OC2.Cl
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Synonyms
RS 21361
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
In Vitro:
DMSO : 125 mg/mL (445.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Protokoll
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Nephrotoxicity Study
This protocol assesses nephrotoxicity by combining functional kidney injury readouts, urinary/tissue injury biomarkers, and renal histopathology. Serum creatinine and BUN reflect impaired kidney function, while KIM-1, NGAL, clusterin, osteopontin, IL-18, cystatin C, nephrin, Oat5, urinary protein, glucose, and alkaline phosphatase have been used to detect tubular injury in cisplatin-, gentamicin-, and acetaminophen-induced nephrotoxicity models.
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. A D Michel, et al. Assessment of imiloxan as a selective alpha 2B-adrenoceptor antagonist. Br J Pharmacol. 1990 Mar;99(3):560-4. [Content Brief]
[2]. Berridge TL, et al. alpha 2-Adrenoceptor agonists induced mydriasis in the rat by an action within the central nervous system. Br J Pharmacol. 1983 Mar;78(3):507-15. [Content Brief]
[3]. Takaomi Shimokawa, et al. Renoprotective effect of yohimbine on ischaemia/reperfusion-induced acute kidney injury through α2C-adrenoceptors in rats. Eur J Pharmacol. 2016 Jun 15;781:36-44. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.5619 mL | 17.8094 mL | 35.6189 mL | 89.0472 mL |
| 5 mM | 0.7124 mL | 3.5619 mL | 7.1238 mL | 17.8094 mL | |
| 10 mM | 0.3562 mL | 1.7809 mL | 3.5619 mL | 8.9047 mL | |
| 15 mM | 0.2375 mL | 1.1873 mL | 2.3746 mL | 5.9365 mL | |
| 20 mM | 0.1781 mL | 0.8905 mL | 1.7809 mL | 4.4524 mL | |
| 25 mM | 0.1425 mL | 0.7124 mL | 1.4248 mL | 3.5619 mL | |
| 30 mM | 0.1187 mL | 0.5936 mL | 1.1873 mL | 2.9682 mL | |
| 40 mM | 0.0890 mL | 0.4452 mL | 0.8905 mL | 2.2262 mL | |
| 50 mM | 0.0712 mL | 0.3562 mL | 0.7124 mL | 1.7809 mL | |
| 60 mM | 0.0594 mL | 0.2968 mL | 0.5936 mL | 1.4841 mL | |
| 80 mM | 0.0445 mL | 0.2226 mL | 0.4452 mL | 1.1131 mL | |
| 100 mM | 0.0356 mL | 0.1781 mL | 0.3562 mL | 0.8905 mL |
Imiloxan hydrochloride Related Classifications
HY-101337A Related Classifications
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