Butabindide
Based on 2 publication(s) in Google Scholar
Butabindide (UCL-1397) is a potent, selective tripeptidvl peptidase II (TPP II) inhibitor with Ki values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide inhibits TPP II to protect CCK-8 against inactivation.
For research use only. We do not sell to patients.
- CAS No.: 175553-48-7
- Formula: C17H25N3O2
- Molecular Weight:303.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Butabindide
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Biological Activity
IC50: 7 nM (TPP II) and 10 μM (TPP I)[1]
Butabindide (UCL-1397; 0-24 nM; membranes of rat cerebral cortex) inhibits TPP II activity of cerebral membranes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice (25-30 g)
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Dosage:10 mg/kg
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Administration:Intravenous injection; for 20 minutes
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Result:Reduces food intake and elicits other behavioral concomitants of satiation.
Chemical Information
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CAS No. 175553-48-7
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Molecular Weight 303.40
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Formula C17H25N3O2
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SMILES
CC[C@H](N)C(N1C2=CC=CC=C2C[C@H]1C(NCCCC)=O)=O
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Synonyms
UCL-1397
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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J Biol Chem
Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding. [Abstract]2018 Dec 7;293(49):18864-18878. PMID: 30291141 -
Purity & Documentation
References
[1]. Ganellin CR, et, al. Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors. J Med Chem. 2005 Nov 17;48(23):7333-42. [Content Brief]
[2]. Rose C, et, al. Characterization and inhibition of a cholecystokinin-inactivating serine peptidase. Nature. 1996 Apr 4;380(6573):403-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Butabindide Related Classifications
HY-150070 Related Classifications
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