1616632-77-9
Chemical Structure
Dordaviprone
Synonym(s): TIC10; ONC-201
- CAS No.: 1616632-77-9
- Formula:C24H26N4O
- Molecular Weight:386.49
IUPAC Name: 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one
InChIKey: VLULRUCCHYVXOH-UHFFFAOYSA-N
SMILES: O=C1N(CC2=CC=CC=C2C)C3=NCCN3C4=C1CN(CC5=CC=CC=C5)CC4
Biological Activity: Dordaviprone (TIC10) is a potent, orally active, and stable tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) inducer which acts by inhibiting Akt and ERK, consequently activating Foxo3a and significantly inducing cell surface TRAIL. Dordaviprone can cross the blood-brain barrier[1].
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Dordaviprone | 99.89% | Dordaviprone (TIC10) is a potent, orally active, and stable tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) inducer which acts by inhibiting Akt and ERK, consequently activating Foxo3a and significantly inducing cell surface TRAIL. Dordaviprone can cross the blood-brain barrier. | ||||||||||||||||||||
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Keywords
