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Cat. No.: HY-P991979

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Erbicin

Erbicin is a single-chain antibody against the human ErbB2 receptor. Erbicin specifically binds to ErbB2-positive cells, inhibits receptor autophosphorylation, and is internalized by target cells. Erbicin can be used in breast cancer-related research.

For research use only. We do not sell to patients.

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Erbicin Chemical Structure

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Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- Species Reactivity
- In Vitro
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Species Reactivity

Human

All EGFR Isoforms :

In Vitro

Erbicin (50-500 nM; 2 h) binds to soluble ErbB2-ECD with a K_d of 50 nM as measured by ELISA, and binds to ErbB2-positive cells with a K_d of 5 nM as measured by ELISA^[1].
Erbicin (5-700 nM; 200 s association, 300 s dissociation) binds to soluble ErbB2-ECD, and its K_d is determined as 46.7 nM by SPR kinetic analysis [1].
Erbicin (~3 μM; 400 s intervals) binds to soluble ErbB2-ECD in solution, with a K_d of 77 nM and a binding stoichiometry of 1:1 measured by ITC^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Gene ID

2064 [NCBI]

Accession

P04626

Target

ERBB2/HER2/CD340

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

Application

ELISA, FACS, Functional assay

Chemical Information

SMILES

[Erbicin]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Inhibitory Antibodies User Guide (603 KB)

References

[1]. Troise F, et al. Differential binding of human immunoagents and Herceptin to the ErbB2 receptor. FEBS J. 2008;275(20):4967-4979. [Content Brief]

[2]. Troise F, et al. A novel ErbB2 epitope targeted by human antitumor immunoagents. FEBS J. 2011;278(7):1156-1166. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- Species Reactivity
- In Vitro
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Purity & Documentation
References

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Erbicin

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

All EGFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Erbicin Related Classifications

HY-P991979 Related Classifications