2. MAPK/ERK Pathway
  3. JNK
  4. IQ-3

IQ-3 is a specific inhibitor of the c-Jun N-terminal kinase (JNK) family, with preference for JNK3. IQ-3 exhibits Kd values of 0.24 μM, 0.29 μM and 0.066 μM for JNK1, JNK2 and JNK3, respectively.

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IQ-3

IQ-3 構造式

CAS 番号 : 312538-03-7

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 108 在庫あり
Solution
10 mM * 1 mL in DMSO USD 108 在庫あり
Solid
5 mg $99 在庫あり
10 mg $154 在庫あり
25 mg $308 在庫あり
50 mg $495 在庫あり
100 mg $825 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 2 publication(s) in Google Scholar

Other Forms of IQ-3:

IQ-3 関連抗体

Top Publications Citing Use of Products

JNK アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
JNK1 JNK2 JNK3 JNK

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製品説明

IQ-3 is a specific inhibitor of the c-Jun N-terminal kinase (JNK) family, with preference for JNK3. IQ-3 exhibits Kd values of 0.24 μM, 0.29 μM and 0.066 μM for JNK1, JNK2 and JNK3, respectively[1].

IC50 & Target[1]

JNK3

0.066 μM (Kd)

JNK1

0.24 μM (Kd)

JNK2

0.29 μM (Kd)

CK1δ

0.56 μM (Kd)

PI3Kγ

0.43 μM (Kd)

MKNK2

1.2 μM (Kd)

体外実験

IQ-3 exhibits IC50 of 2.2 μM (TNF-α in human monoMac-6 cells), 1.5 μM (IL-6 in human monoMac-6 cells), 4.7 μM (TNF-α in human PBMCs), 9.1 μM (IL-6 in human PBMCs) and 6.1 μM (NO in murine J774.A1), respectively[1].
IQ-3 exhibits an IC50 of 1.4 μM for inhibiting LPS-induced NF-κB/AP-1 transcriptional activity in human THP-1 Blue monocytic cells[1].
IQ-3 is indeed a competitive inhibitor for the ATP binding site of JNK3[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IQ-3 関連抗体

Cell Viability Assay[1]

Cell Line: PBMCs.
Concentration: 0-80 μM (200 ng/mL LPS).
Incubation Time: 30 min.
Result: Downregulated TNF-α concentration (IC50 = 4.7 μM).
臨床実験
分子量

341.32

分子式

C20H11N3O3
CAS 番号
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O/N=C1C2=C(C3=NC4=CC=CC=C4N=C3\1)C=CC=C2)C5=CC=CO5
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 25 mg/mL (73.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9298 mL 14.6490 mL 29.2980 mL
5 mM 0.5860 mL 2.9298 mL 5.8596 mL
10 mM 0.2930 mL 1.4649 mL 2.9298 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  15% Cremophor EL    85% Saline

    Solubility: 1.25 mg/mL (3.66 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9298 mL 14.6490 mL 29.2980 mL 73.2450 mL
5 mM 0.5860 mL 2.9298 mL 5.8596 mL 14.6490 mL
10 mM 0.2930 mL 1.4649 mL 2.9298 mL 7.3245 mL
15 mM 0.1953 mL 0.9766 mL 1.9532 mL 4.8830 mL
20 mM 0.1465 mL 0.7325 mL 1.4649 mL 3.6623 mL
25 mM 0.1172 mL 0.5860 mL 1.1719 mL 2.9298 mL
30 mM 0.0977 mL 0.4883 mL 0.9766 mL 2.4415 mL
40 mM 0.0732 mL 0.3662 mL 0.7325 mL 1.8311 mL
50 mM 0.0586 mL 0.2930 mL 0.5860 mL 1.4649 mL
60 mM 0.0488 mL 0.2442 mL 0.4883 mL 1.2208 mL
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IQ-3 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IQ-3312538-03-7IQ3IQ 3JNKc-Jun N-terminal kinaseTNF-αIL-6IL-1αIL-1βInhibitorinhibitorinhibit

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製品名:
IQ-3
製品番号:
HY-107600
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