2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog
  4. Isocytidine

2-Amino-1-β-D-ribofuranosyl-4(1H)-pyrimidinone is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

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Isocytidine

Isocytidine Chemical Structure

CAS No. : 489-59-8

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Based on 1 publication(s) in Google Scholar

Isocytidine Related Antibodies

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Description

2-Amino-1-β-D-ribofuranosyl-4(1H)-pyrimidinone is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Molecular Weight

243.22

Formula

C9H13N3O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1N=C(N)N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (205.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1115 mL 20.5575 mL 41.1150 mL
5 mM 0.8223 mL 4.1115 mL 8.2230 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.1115 mL 20.5575 mL 41.1150 mL 102.7876 mL
5 mM 0.8223 mL 4.1115 mL 8.2230 mL 20.5575 mL
10 mM 0.4112 mL 2.0558 mL 4.1115 mL 10.2788 mL
15 mM 0.2741 mL 1.3705 mL 2.7410 mL 6.8525 mL
20 mM 0.2056 mL 1.0279 mL 2.0558 mL 5.1394 mL
25 mM 0.1645 mL 0.8223 mL 1.6446 mL 4.1115 mL
30 mM 0.1371 mL 0.6853 mL 1.3705 mL 3.4263 mL
40 mM 0.1028 mL 0.5139 mL 1.0279 mL 2.5697 mL
50 mM 0.0822 mL 0.4112 mL 0.8223 mL 2.0558 mL
60 mM 0.0685 mL 0.3426 mL 0.6853 mL 1.7131 mL
80 mM 0.0514 mL 0.2570 mL 0.5139 mL 1.2848 mL
100 mM 0.0411 mL 0.2056 mL 0.4112 mL 1.0279 mL
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Isocytidine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isocytidine489-59-8Nucleoside Antimetabolite/Analogindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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