Auristatin E-d8
Based on 1 Customer Validation
Auristatin E-d8 is the deuterium labeled Auristatin E (HY-15582). Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 (HY-15580), is linear peptides comprised of four amino acids.
For research use only. We do not sell to patients.
- Purity: 99.48%
- Formula: C40H61D8N5O7
- Molecular Weight:740.05
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled Cas 160800-57-7
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Appearance Solid
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Molecular Weight 740.05
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Formula C40H61D8N5O7
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Color White to off-white
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SMILES
CC(C)[C@H](N(C)C)C(NC(C(N([C@@H]([C@@H](C)CC)[C@@H](CC(N1CCC[C@@]1([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)=O)OC)C)=O)([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (135.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3513 mL | 6.7563 mL | 13.5126 mL | 33.7815 mL |
| 5 mM | 0.2703 mL | 1.3513 mL | 2.7025 mL | 6.7563 mL | |
| 10 mM | 0.1351 mL | 0.6756 mL | 1.3513 mL | 3.3782 mL | |
| 15 mM | 0.0901 mL | 0.4504 mL | 0.9008 mL | 2.2521 mL | |
| 20 mM | 0.0676 mL | 0.3378 mL | 0.6756 mL | 1.6891 mL | |
| 25 mM | 0.0541 mL | 0.2703 mL | 0.5405 mL | 1.3513 mL | |
| 30 mM | 0.0450 mL | 0.2252 mL | 0.4504 mL | 1.1261 mL | |
| 40 mM | 0.0338 mL | 0.1689 mL | 0.3378 mL | 0.8445 mL | |
| 50 mM | 0.0270 mL | 0.1351 mL | 0.2703 mL | 0.6756 mL | |
| 60 mM | 0.0225 mL | 0.1126 mL | 0.2252 mL | 0.5630 mL | |
| 80 mM | 0.0169 mL | 0.0845 mL | 0.1689 mL | 0.4223 mL | |
| 100 mM | 0.0135 mL | 0.0676 mL | 0.1351 mL | 0.3378 mL |
Auristatin E-d8 Related Classifications
HY-15582S Related Classifications
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