BAPTA tetrasodium
Based on 37 publication(s) in Google Scholar
BAPTA tetrasodium is a selective and cell-impermeant chelator for calcium. BAPTA tetrasodium has high selectivity against magnesium and calcium. BAPTA can also inhibit phospholipase C activity independently of their role as Ca2+ chelators.
For research use only. We do not sell to patients.
- Purity: 99.70%
- CAS No.: 126824-24-6
- Formula: C22H20N2Na4O10
- Molecular Weight:564.36
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) BAPTA tetrasodium
More- Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]
- Sci Immunol. 2019 Jun 28;4(36):eaau6426. [Abstract]
- J Clin Invest. 2024 Apr 25;134(12):e176355. [Abstract]
- Adv Sci (Weinh). 2021 Aug;8(15):e2100363. [Abstract]
- Environ Chem Ecotoxicol. 2025 Nov 19;8:267-280.
- J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]
- Cell Death Discov. 2026 May 25. [Abstract]
- Free Radic Biol Med. 2024 Mar:213:150-163. [Abstract]
- Cell Rep. 2025 Dec 10;44(12):116673. [Abstract]
- J Pineal Res. 2024 Aug;76(5):e12987. [Abstract]
- J Ginseng Res. 2022 Jul;46(4):515-525. [Abstract]
- J Invest Dermatol. 2024 Dec;144(12):2695-2705.e8. [Abstract]
- J Ethnopharmacol. 2025 May 28:348:119863. [Abstract]
- J Ethnopharmacol. 2023 Feb 10;302(Pt A):115923. [Abstract]
- Int J Pharm. 2025 Nov 10:684:126125. [Abstract]
- Int J Mol Sci. 2026 Jan 1;27(1):468. [Abstract]
- Int Immunopharmacol. 2026 Mar 1:172:116168. [Abstract]
- Toxicology. 2023 Dec:500:153674. [Abstract]
- J Thromb Haemost. 2021 Dec;19(12):3113-3125. [Abstract]
- Biochim Biophys Acta Mol Basis Dis. 2025 Jul 18;1871(8):167990. [Abstract]
- Mol Med Rep. 2024 Jan;29(1):13. [Abstract]
- Exp Neurol. 2023 May:363:114350. [Abstract]
- Cell Signal. 2025 Jul:131:111753. [Abstract]
- J Cell Mol Med. 2020 Aug;24(16):9287-9299. [Abstract]
- J Funct Foods. 2024 Oct.
- J Funct Foods. December 2021, 104791.
- J Pharm Pharmacol. 2024 May 3;76(5):567-578. [Abstract]
- J Cancer. 2024 Jan 1;15(2):343-355. [Abstract]
- Toxicon. 2026 Jun 15:276:109072. [Abstract]
- Cardiovasc Ther. 2023 Mar 30:2023:3939360. [Abstract]
- Vet Microbiol. 2019 Dec:239:108498. [Abstract]
- Res Sq. 2025 Apr 18.
- Biomed Pharmacother. 2023 Oct:166:115343. [Abstract]
- bioRxiv. 2023 Jun 25.
- Biomed Pharmacother. 2023 May:161:114480. [Abstract]
- Sci Total Environ. 2020 Feb 10:703:134702. [Abstract]
- Aging. 2019 Nov 22;11(22):10385-10408. [Abstract]
Customer Validation & Images
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WB
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IF
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RT-PCR
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ELISA
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IF
All Phospholipase Isoforms
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Biological Activity
BAPTA tetrasodium is widely used as an intracellular buffer to investigate the effects caused by Ca2+ release from intracellular calcium stores or Ca2+ influx via Ca2+-permeable channels in the plasma membrane[1].
BAPTA tetrasodium can be introduced into cells via methods such as patch-clamp and microinjection[1].
BAPTA tetrasodium inhibits PLC activity in isolated Drosophila melanogaster photoreceptor cells with an IC50 of approximately 8 mM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 126824-24-6
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Appearance Solid
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Molecular Weight 564.36
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Formula C22H20N2Na4O10
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Color White to off-white
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SMILES
O=C(O[Na])CN(C1=CC=CC=C1OCCOC2=CC=CC=C2N(CC(O[Na])=O)CC(O[Na])=O)CC(O[Na])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (37)
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Journal Impact Factor
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Most Recent
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Mil Med Res
Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways. [Abstract]2023 Nov 25;10(1):56. PMID: 38001521
BAPTA tetrasodium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]
BAPTA (10 μmol/L, 24 h). qRT-PCR was used to assess the mRNA level of Il6, Tnfα and Tgfβ3 in HMs.
BAPTA tetrasodium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]
BAPTA (10 μmol/L, 24 h). TGF-β1 and IL-6 level in the supernatant of HMs were detected by ELISA.
BAPTA tetrasodium purchased from MedChemExpress. Usage Cited in: Mil Med Res. 2023 Nov 25;10(1):56. [Abstract]
BAPTA (10 μmol/L, 24 h). The expression and location of TNF-α in HMs was assessed by confocal microscopy (c). Scale bar = 20 μm.
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Sci Immunol
2019 Jun 28;4(36):eaau6426. PMID: 31253642 -
J Clin Invest
Chromosomal 3q amplicon encodes essential regulators of secretory vesicles that drive secretory addiction in cancer. [Abstract]2024 Apr 25;134(12):e176355. PMID: 38662435 -
Adv Sci (Weinh)
2021 Aug;8(15):e2100363. PMID: 34047068 -
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J Neuroinflammation
P2X7-CaMKII drives 5-LOX nuclear translocation to impair microglial function after subarachnoid hemorrhage. [Abstract]2025 Aug 28;22(1):208. PMID: 40877894
BAPTA tetrasodium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]
BAPTA (10 μM). WB results showed that BAPTA could attenuate the Hb-induced decrease in LAMP1 and m-CTSD/pro-CTSD.
BAPTA tetrasodium purchased from MedChemExpress. Usage Cited in: J Neuroinflammation. 2025 Aug 28;22(1):208. [Abstract]
IF results showed that BAPTA (10 μM) can partially increase the co-localization coefficients of LAMP1 and CTSD.
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Cell Death Discov
ATP2B4 driven chromatin compaction exacerbates pancreatic cancer radiotherapy resistance. [Abstract]2026 May 25. PMID: 42185253 -
Free Radic Biol Med
Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes. [Abstract]2024 Mar:213:150-163. PMID: 38190923 -
Cell Rep
Aryl hydrocarbon receptor-induced activation of AIM2 inflammasome is mediated by MOMP and MPT: A vital therapeutic pathway for inflammation. [Abstract]2025 Dec 10;44(12):116673. PMID: 41385364 -
J Pineal Res
2024 Aug;76(5):e12987. PMID: 38975671 -
J Ginseng Res
Ginsenoside Rg1 attenuates cerebral ischemia-reperfusion injury due to inhibition of NOX2-mediated calcium homeostasis dysregulation in mice. [Abstract]2022 Jul;46(4):515-525. PMID: 35818419 -
J Invest Dermatol
TRPV3-Activated PARP1/AIFM1/MIF Axis through Oxidative Stress Contributes to Atopic Dermatitis. [Abstract]2024 Dec;144(12):2695-2705.e8. PMID: 38823435 -
J Ethnopharmacol
Ginsenoside Rg1 attenuates T2DM-induced renal damage and fibrosis by inhibiting TRPC6-ChREBP-TXNIP signaling. [Abstract]2025 May 28:348:119863. PMID: 40311716 -
J Ethnopharmacol
Ginsenoside Rg1 attenuates glomerular fibrosis by inhibiting CD36/TRPC6/NFAT2 signaling in type 2 diabetes mellitus mice. [Abstract]2023 Feb 10;302(Pt A):115923. PMID: 36375645 -
Int J Pharm
Reversible increased basement membrane permeability and calcium ion redistribution facilitate ultrasound-enhanced transdermal drug delivery efficiency. [Abstract]2025 Nov 10:684:126125. PMID: 40914558 -
Int J Mol Sci
Gut Microbiota-Derived Propionic Acid Mediates ApoA-I-Induced Amelioration of MASLD via Activation of GPR43-Ca2+-CAMKII-ATGL Hepatic Lipolysis. [Abstract]2026 Jan 1;27(1):468. PMID: 41516340 -
Int Immunopharmacol
Piezo1 activates Wnt5a/FZD4 signaling to promote osteogenesis and mitigates age-associated bone loss. [Abstract]2026 Mar 1:172:116168. PMID: 41529412 -
Toxicology
Nonivamide inhibits proliferation of human corneal epithelial cells by inducing cell cycle arrest and oxidative stress. [Abstract]2023 Dec:500:153674. PMID: 37989449 -
J Thromb Haemost
2021 Dec;19(12):3113-3125. PMID: 34411418 -
Biochim Biophys Acta Mol Basis Dis
Activation of IRF2 signaling networks facilitates podocyte pyroptosis in lupus nephritis. [Abstract]2025 Jul 18;1871(8):167990. PMID: 40684959 -
Mol Med Rep
Trpc6 knockout protects against renal fibrosis by restraining the CN‑NFAT2 signaling pathway in T2DM mice. [Abstract]2024 Jan;29(1):13. PMID: 38038121 -
Exp Neurol
Trpc6 knockout improves behavioral dysfunction and reduces Aβ production by inhibiting CN-NFAT1 signaling in T2DM mice. [Abstract]2023 May:363:114350. PMID: 36791875 -
Cell Signal
Rosuvastatin inhibits carcinogenesis through Ca2+ triggered endoplasmic reticulum stress pathway in pancreatic cancer. [Abstract]2025 Jul:131:111753. PMID: 40107481 -
J Cell Mol Med
Calpain-2 plays a pivotal role in the inhibitory effects of propofol against TNF-α-induced autophagy in mouse hippocampal neurons. [Abstract]2020 Aug;24(16):9287-9299. PMID: 32627970 -
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J Pharm Pharmacol
2024 May 3;76(5):567-578. PMID: 38271051 -
J Cancer
JS-K activates G2/M checkpoints through the DNA damage response and induces autophagy via CAMKKβ/AMPKα/mTOR pathway in bladder cancer cells. [Abstract]2024 Jan 1;15(2):343-355. PMID: 38169515 -
Toxicon
Transient receptor potential canonical 6 is critical for chronic lipopolysaccharide exposure-induced pulmonary injury and fibrosis. [Abstract]2026 Jun 15:276:109072. PMID: 41850440 -
Cardiovasc Ther
KCa3.1 Promotes Proinflammatory Exosome Secretion by Activating AKT/Rab27a in Atrial Myocytes during Rapid Pacing. [Abstract]2023 Mar 30:2023:3939360. PMID: 37035755 -
Vet Microbiol
S100A9 regulates porcine reproductive and respiratory syndrome virus replication by interacting with the viral nucleocapsid protein. [Abstract]2019 Dec:239:108498. PMID: 31767072 -
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Biomed Pharmacother
Barasertib impedes chondrocyte senescence and alleviates osteoarthritis by mitigating the destabilization of heterochromatin induced by AURKB. [Abstract]2023 Oct:166:115343. PMID: 37634474 -
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Biomed Pharmacother
Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm. [Abstract]2023 May:161:114480. PMID: 37002575 -
Sci Total Environ
Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons. [Abstract]2020 Feb 10:703:134702. PMID: 31753492 -
Aging
Rotating magnetic field delays human umbilical vein endothelial cell aging and prolongs the lifespan of Caenorhabditis elegans. [Abstract]2019 Nov 22;11(22):10385-10408. PMID: 31757933
Solvent & Solubility
H2O : 100 mg/mL (177.19 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. R Y Tsien, et al. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry. 1980 May 27;19(11):2396-404. [Content Brief]
[2]. Roger C Hardie, et al. Inhibition of phospholipase C activity in Drosophila photoreceptors by 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid (BAPTA) and di-bromo BAPTA. Cell Calcium. 2005 Dec;38(6):547-56. [Content Brief]
[3]. M B Collatz, et al. Intracellular calcium chelator BAPTA protects cells against toxic calcium overload but also alters physiological calcium responses. Cell Calcium [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.7719 mL | 8.8596 mL | 17.7192 mL | 44.2980 mL |
| 5 mM | 0.3544 mL | 1.7719 mL | 3.5438 mL | 8.8596 mL | |
| 10 mM | 0.1772 mL | 0.8860 mL | 1.7719 mL | 4.4298 mL | |
| 15 mM | 0.1181 mL | 0.5906 mL | 1.1813 mL | 2.9532 mL | |
| 20 mM | 0.0886 mL | 0.4430 mL | 0.8860 mL | 2.2149 mL | |
| 25 mM | 0.0709 mL | 0.3544 mL | 0.7088 mL | 1.7719 mL | |
| 30 mM | 0.0591 mL | 0.2953 mL | 0.5906 mL | 1.4766 mL | |
| 40 mM | 0.0443 mL | 0.2215 mL | 0.4430 mL | 1.1074 mL | |
| 50 mM | 0.0354 mL | 0.1772 mL | 0.3544 mL | 0.8860 mL | |
| 60 mM | 0.0295 mL | 0.1477 mL | 0.2953 mL | 0.7383 mL | |
| 80 mM | 0.0221 mL | 0.1107 mL | 0.2215 mL | 0.5537 mL | |
| 100 mM | 0.0177 mL | 0.0886 mL | 0.1772 mL | 0.4430 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
BAPTA tetrasodium Related Classifications
HY-100168A Related Classifications
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