DOCK2-IN-1
Based on 1 Customer Validation
DOCK2-IN-1 (Compound 3) is an analog of CPYPP (HY-110100) and a DOCK2 inhibitor (IC50 = 19.1 μM). DOCK2-IN-1 binds to the DHR-2 domain of DOCK2 and inhibits its mediated Rac guanine nucleotide exchange factor activity. DOCK2-IN-1 blocks chemokine receptor- and antigen receptor-mediated activation of Rac in lymphocytes. DOCK2-IN-1 significantly inhibits chemotaxis and T cell activation. DOCK2-IN-1 can be used in the research of transplant rejection and organ-specific autoimmune diseases.
For research use only. We do not sell to patients.
- Purity: 99.37%
- CAS No.: 4590-86-7
- Formula: C16H11ClN2O2
- Molecular Weight:298.72
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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DOCK2 19.1 μM (IC50) |
DOCK2-IN-1 (0.1-100 μM; 2-30 min) potently inhibits the Rac1 guanine nucleotide exchange factor activity of purified DOCK2DHR-2 protein, with an IC50 of 19.1 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 4590-86-7
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Appearance Solid
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Molecular Weight 298.72
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Formula C16H11ClN2O2
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Color Brown to reddish brown
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SMILES
O=C1NN(C(/C1=C/C2=C(Cl)C=CC=C2)=O)C3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (334.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.3476 mL | 16.7381 mL | 33.4762 mL | 83.6904 mL |
| 5 mM | 0.6695 mL | 3.3476 mL | 6.6952 mL | 16.7381 mL | |
| 10 mM | 0.3348 mL | 1.6738 mL | 3.3476 mL | 8.3690 mL | |
| 15 mM | 0.2232 mL | 1.1159 mL | 2.2317 mL | 5.5794 mL | |
| 20 mM | 0.1674 mL | 0.8369 mL | 1.6738 mL | 4.1845 mL | |
| 25 mM | 0.1339 mL | 0.6695 mL | 1.3390 mL | 3.3476 mL | |
| 30 mM | 0.1116 mL | 0.5579 mL | 1.1159 mL | 2.7897 mL | |
| 40 mM | 0.0837 mL | 0.4185 mL | 0.8369 mL | 2.0923 mL | |
| 50 mM | 0.0670 mL | 0.3348 mL | 0.6695 mL | 1.6738 mL | |
| 60 mM | 0.0558 mL | 0.2790 mL | 0.5579 mL | 1.3948 mL | |
| 80 mM | 0.0418 mL | 0.2092 mL | 0.4185 mL | 1.0461 mL | |
| 100 mM | 0.0335 mL | 0.1674 mL | 0.3348 mL | 0.8369 mL |
DOCK2-IN-1 Related Classifications
HY-153128 Related Classifications
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