Mpl - myeloproliferative leukemia virus oncogene Gene

Also Known as CD110; TPO-R; c-mpl; hlb219

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17480

About Mpl

Chromosome 4: 118,299,612-118,314,710 reverse strand.GRCm39:CM000997.3

This gene has 5 transcripts (splice variants), 186 orthologues, 8 paralogues and is associated with 18 phenotypes. Biased expression in spleen adult (RPKM 4.4), liver E14.5 (RPKM 3.8) and 7 other tissues.

Summary

Predicted to enable Thrombopoietin Receptor activity. Involved in thrombopoietin-mediated signaling pathway. Acts upstream of or within several processes, including hemopoiesis; regulation of gene expression; and regulation of stem cell division. Predicted to be located in several cellular components, including Golgi apparatus; neuronal cell body; and nuclear membrane. Is expressed in several structures, including brain; hemolymphoid system; mesenchyme derived from splanchnopleure; reproductive system; and spinal cord. Used to study congenital amegakaryocytic thrombocytopenia. Human ortholog(s) of this gene implicated in congenital amegakaryocytic thrombocytopenia; essential thrombocythemia; myelofibrosis; thrombocytopenia; and thrombocytosis. Orthologous to human MPL (MPL proto-oncogene, Thrombopoietin Receptor). [provided by Alliance of Genome Resources, Apr 2022]

Mpl Products (4)

mRNA Protein Name
NM_001285496.1 NP_001272425.1 thrombopoietin receptor isoform 3 precursor
NM_001122949.2 NP_001116421.1 thrombopoietin receptor isoform 1 precursor
NM_001285497.1 NP_001272426.1 thrombopoietin receptor isoform 4 precursor
NM_010823.3 NP_034953.2 thrombopoietin receptor isoform 2 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within definitive hemopoiesis IMP
IMP: Inferred from mutant phenotype
20711984 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: Inferred from mutant phenotype
20643340 MGI
acts upstream of or within negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20711984 MGI
acts upstream of or within platelet formation IGI
IGI: Inferred from genetic interaction
18684867 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20711984 MGI
acts upstream of or within regulation of chemokine production IMP
IMP: Inferred from mutant phenotype
20643340 MGI
acts upstream of or within regulation of stem cell division IMP
IMP: Inferred from mutant phenotype
20711984 MGI
acts upstream of or within regulation of stem cell proliferation IMP
IMP: Inferred from mutant phenotype
20711984 MGI
involved in thrombopoietin-mediated signaling pathway IDA
IDA: Inferred from direct assay
25468569 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mpl Protein Structure

EpoR_lig-bind

EpoR_lig-bind: pfam09067 (24 - 127)

FN3

FN3: cd00063 (386 - 475)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 625 a.a.
Protein Preferred Names Protein Names

thrombopoietin receptor

  • myeloproliferative leukemia protein

  • proto-oncogene c-Mpl

Recombinant Mpl Proteins

Cat. No. Product Name Accession Purity
HY-P78003 C-MPL Protein, Mouse (HEK293, His) Q08351 (Q26-W482) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-NP074 Maclura Pomifera Lectin / Phase 3

Pre-clinical Phase

Bioactive Molecules (17)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148748 Butyzamide Activator 99.83% Unkown
HY-112486 TA-316 99.50% Unkown
HY-122620 Rafutrombopag (tautomerism) 98.33% Unkown
HY-112486G TA-316 (GMP) Agonist / Unkown
HY-148748G Butyzamide (GMP) Activator / Unkown
HY-145589 Rafutrombopag 95.29% Unkown
HY-144002 RIBI-529 / Unkown
HY-RS08616 MPL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-159671A 3D-Monophosphoryl Lipid (14) triethylamine Agonist / Unkown
HY-159671B 3D-Monophosphoryl Lipid (14) ammonium Agonist / Unkown
HY-159672 3D-Monophosphoryl Lipid (12,16) Agonist / Unkown
HY-159672A 3D-Monophosphoryl Lipid (12,16) free acid Agonist / Unkown
HY-159672B 3D-Monophosphoryl Lipid (12,16) triethylamine Agonist / Unkown
HY-182369 VA06 Inhibitor / Unkown
HY-RS08617 Mpl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08618 Mpl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-159671 3D-Monophosphoryl Lipid (14) Agonist / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990685 Romiplostim Agonist ≥99.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mpl NCBI NCBI:4352