TTLL10 - tubulin tyrosine ligase like 10 Gene

Also Known as TTLL5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 254173

Summary

Predicted to enable protein-glycine Ligase activity, elongating. Predicted to be involved in protein polyglycylation. Predicted to be located in axoneme and microtubule Cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]
Biased expression in testis (RPKM 6.9), lung (RPKM 0.7) and 1 other tissue.

TTLL10 Products (3)

mRNA Protein Name
NM_001130045.2 NP_001123517.1 inactive polyglycylase TTLL10 isoform 1
NM_001371649.1 NP_001358578.1 inactive polyglycylase TTLL10 isoform 1
NM_153254.3 NP_694986.2 inactive polyglycylase TTLL10 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18331838 GOA
NOT enables protein-glycine ligase activity IDA
IDA: Inferred from direct assay
19524510 GOA
Biological Process GO Annotation Evidence References Source
NOT involved in protein polyglycylation IDA
IDA: Inferred from direct assay
19524510 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TTLL10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TTLL10 Q6ZVT0 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
25416956
Intra
TTLL10 Q6ZVT0 PNMA2 Homo sapiens Q9UL42
Y2H Prey Pooling
25416956
Intra
TTLL10 Q6ZVT0 NAP1L1 Homo sapiens P55209
Anti Bait CoIP
18331838
Intra
TTLL10 Q6ZVT0 NAP1L1 Homo sapiens P55209
Anti Tag CoIP
18331838
Intra
TTLL10 Q6ZVT0 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
TTLL10 Q6ZVT0 MDFI Homo sapiens Q99750
Validated Y2H
25416956
Intra
TTLL10 Q6ZVT0 MDFI Homo sapiens Q99750
Y2H Prey Pooling
25416956
Intra
TTLL10 Q6ZVT0 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
25416956
Intra
TTLL10 Q6ZVT0 CEP70 Homo sapiens Q8NHQ1
Y2H Array
25416956
Intra
TTLL10 Q6ZVT0 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
25416956
Intra
TTLL10 Q6ZVT0 RBPMS Homo sapiens Q93062
Validated Y2H
25416956
Intra
TTLL10 Q6ZVT0 FHL3 Homo sapiens Q13643
Y2H Array
25416956
Intra
TTLL10 Q6ZVT0 THAP1 Homo sapiens Q9NVV9
Y2H Prey Pooling
25416956
Intra
TTLL10 Q6ZVT0 THAP1 Homo sapiens Q9NVV9
Y2H Array
25416956
Intra
TTLL10 Q6ZVT0 TRIP6 Homo sapiens Q15654
Y2H Prey Pooling
25416956
Intra
TTLL10 Q6ZVT0 TRIP6 Homo sapiens Q15654
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15228 TTLL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15229 TTLL12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21967 Ttll12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28484 Ttll12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown