LGALS4 - galectin 4 Gene

Also Known as GAL4; L36LBP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3960

About LGALS4

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,801,674-38,812,945 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 244 orthologues and 16 paralogues. Biased expression in colon (RPKM 740.5), duodenum (RPKM 465.8) and 4 other tissues.

Summary

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The expression of this gene is restricted to small intestine, colon, and rectum, and it is underexpressed in colorectal Cancer. [provided by RefSeq, Jul 2008]

LGALS4 Products (1)

mRNA	Protein	Name
NM_006149.4	NP_006140.1	galectin-4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	26481311	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LGALS4 Protein Structure

Gal-bind_lectin

0
100
200
300
323 a.a.

Protein Preferred Names	Protein Names
galectin-4	L-36 lactose-binding protein

LGALS4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LGALS4	P56470	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Prey Pooling	32296183
Intra	LGALS4	P56470	KRTAP11-1	Homo sapiens	Q8IUC1	Y2H Array	32296183
Intra	LGALS4	P56470	KRTAP11-1	Homo sapiens	Q8IUC1	Validated Y2H	32296183
Intra	LGALS4	P56470	NCKIPSD	Homo sapiens	Q9NZQ3-3	Validated Y2H	32296183
Intra	LGALS4	P56470	NCKIPSD	Homo sapiens	Q9NZQ3-3	Y2H Prey Pooling	32296183
Intra	LGALS4	P56470	NCKIPSD	Homo sapiens	Q9NZQ3-3	Y2H Array	32296183
Intra	LGALS4	P56470	BANP	Homo sapiens	Q8N9N5-2	Y2H Array	32296183
Intra	LGALS4	P56470	BANP	Homo sapiens	Q8N9N5-2	Y2H Prey Pooling	32296183
Intra	LGALS4	P56470	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	LGALS4	P56470	EYA2	Homo sapiens	O00167-2	Y2H Prey Pooling	32296183
Intra	LGALS4	P56470	EYA2	Homo sapiens	O00167-2	Y2H Array	32296183
Intra	LGALS4	P56470	TOX2	Homo sapiens	Q96NM4-3	Validated Y2H	32296183
Intra	LGALS4	P56470	TOX2	Homo sapiens	Q96NM4-3	Y2H Array	32296183
Intra	LGALS4	P56470	TOX2	Homo sapiens	Q96NM4-3	Y2H Prey Pooling	32296183
Intra	LGALS4	P56470	TENM4	Homo sapiens	Q6N022	Validated Y2H	32296183
Intra	LGALS4	P56470	TENM4	Homo sapiens	Q6N022	Y2H Array	32296183
Intra	LGALS4	P56470	TENM4	Homo sapiens	Q6N022	Y2H Prey Pooling	32296183
Intra	LGALS4	P56470	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	LGALS4	P56470	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	LGALS4	P56470	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	LGALS4	P56470	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	LGALS4	P56470	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	LGALS4	P56470	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	LGALS4	P56470	RFX6	Homo sapiens	Q8HWS3	Y2H Array	32296183
Intra	LGALS4	P56470	RFX6	Homo sapiens	Q8HWS3	Y2H Prey Pooling	32296183
Intra	LGALS4	P56470	RFX6	Homo sapiens	Q8HWS3	Validated Y2H	32296183
Intra	LGALS4	P56470	CEP55	Homo sapiens	Q53EZ4	Validated Y2H	32296183
Intra	LGALS4	P56470	CEP55	Homo sapiens	Q53EZ4	Y2H Array	32296183
Intra	LGALS4	P56470	CEP55	Homo sapiens	Q53EZ4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LGALS4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72638	Galectin-4/LGALS4 Protein, Human (His)	P56470 (M1-I323)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P72638AF	Animal-Free Galectin-4/LGALS4 Protein, Human (His)	P56470 (A2-I323)	≥ 95%, as determined by reducing SDS-PAGE.

LGALS4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83632	GAL4 Antibody (YA3377)	WB, IHC-P	Human, Rat

Related Diseases

Diseases	Alias
Greig Cephalopolysyndactyly Syndrome	GCPS Polysyndactyly With Peculiar Skull Shape Polysyndactyly With Peculiars Skull Shape Greig Syndrome Cephalopolysyndactyly Syndrome Greig Cephalo-Poly-Syndactyly Syndrome Cephalopolysyndactyly, Greig Syndrome Aarskog Syndrome
Hyperinsulinemic Hypoglycemia, Familial, 4	Hyperinsulinism Due To Glutamodehydrogenase Deficiency HHF4 Familial Hyperinsulinemic Hypoglycemia 4 Hyperinsulinemic Hypoglycemia Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency Hyperinsulinism Due To Schad Deficiency Hyperinsulinism Due To Short Chain 3-Hydroxylacyl-Coa Dehydrogenase Deficiency Congenital Hyperinsulinism Schad Deficiency Persistent Hyperinsulinemic Hypoglycemia Of Infancy Phhi 3-Hydroxyacyl-Coa Dehydrogenase Deficiency
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Gastrointestinal Carcinoma	Gastrointestinal Neoplasms
Spermatogenic Failure 11	SPGF11
Amyloidosis, Familial Visceral	Ostertag Type Amyloidosis German Type Amyloidosis Familial Renal Amyloidosis Amyloidosis Viii Amyloidosis, 3 Or More Types Familial Visceral Amyloidosis Familial Amyloid Nephropathy Hereditary Amyloid Nephropathy Amyloidosis, Familial Renal Amyloidosis, Systemic Nonneuropathic Amyloidosis Familial Visceral Amyloidosis 8 Amyloidosis, Ostertag Type Hereditary Amyloidosis With Primary Renal Involvement Hereditary Renal Amyloidosis Renal Amyloidosis Amyloidosis, Renal Systemic Nonneuropathic Amyloidosis Amyloidosis Familial Renal Amyloidosis Systemic Nonneuropathic Hereditary Amyloidosis With Primary Renal Involement AMYL8 Systemic Non-Neuropathic Amyloidosis Amyloid Nephropathy
Amelogenesis Imperfecta, Type Iiic	AI3C Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Recessive Amelogenesis Imperfecta Type 3c Amelogenesis Imperfecta, Type 3c Amelogenesis Imperfecta Type Iiic Autosomal Recessive Amelogenesis Imperfecta Hypocalcification Type Amelogenesis Imperfecta 3c
Retinitis Pigmentosa 46	RP46 Retinitis Pigmentosa, Autosomal Recessive, Idh3b-Related Retinitis Pigmentosa Autosomal Recessive Idh3b-Related Retinitis Pigmentosa, Type 46
Colon Adenocarcinoma	Adenocarcinoma Of Colon Adenocarcinoma Of The Colon Colonic Adenocarcinoma
Oliver-Mcfarlane Syndrome	Trichomegaly-Retina Pigmentary Degeneration-Dwarfism Syndrome OMCS Long Eyelashes-Intellectual Disability Syndrome Trichomegaly With Mental Retardation, Dwarfism, And Pigmentary Degeneration Of Retina Eyelashes, Long, With Mental Retardation Eyelashes Long Mental Retardation Trichomegaly With Intellectual Disability, Dwarfism And Pigmentary Degeneration Trichomegaly With Intellectual Disability, Dwarfism And Pigmentary Degeneration Of Retina Eyelashes, Long With Intellectual Disability Oliver Mcfarlane Syndrome Congenital Trichomegaly, Pigmentary Retinal Degeneration, And Short Stature Trichomegaly, Retina Pigmentary Degeneration, Dwarfism Trichomegaly Retina Pigmentary Degeneration Dwarfism
Advanced Sleep Phase Syndrome, Familial, 3	Advanced Sleep Phase Syndrome 3 FASPS3 Familial Advanced Sleep Phase Syndrome 3 Sleep Phase Syndrome, Advanced, Familial, Type 3
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1	Eec Syndrome Rudiger Syndrome 1 Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 1 EEC1 Eec Syndrome 1 Eec Syndrome-1 Walker-Clodius Syndrome Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome Eec Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome Ectrodactyly-Cleft Lip/Palate Syndrome Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Cleft Palate Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome Ectrodactyly, Ectodermal Dysplasia, Clefting Syndrome Ectrodactyly-Cleft Lip-Palate Syndrome Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome
Optic Atrophy 10 With Or Without Ataxia, Mental Retardation, And Seizures	OPA10 Optic Atrophy 10 With Or Without Ataxia, Intellectual Disability, And Seizures Optic Atrophy 10 Atrophy, Optic, Type 10, With/Without Ataxia, Mental Retardation, And Seizures
Rapp-Hodgkin Syndrome	RHS Anhidrotic Ectodermal Dysplasia With Cleft Lip/Palate Ectodermal Dysplasia, Rapp-Hodgkin Type Rapp-Hodgkin Ectodermal Dysplasia Syndrome Ectodermal Dysplasia, Anhidrotic, With Cleft Lip/Palate Ectodermal Dysplasia Syndrome, Rapp-Hodgkin Type Edrh Rapp-Hodgkin Ectodermal Dysplasia Orofacial Cleft 8
Parkinson Disease 17	PARK17 Parkinson'S Disease 17 Autosomal Dominant Parkinson Disease 17 Parkinson Disease, Type 17
Spondylocostal Dysostosis 3, Autosomal Recessive	SCDO3 Spondylocostal Dysostosis, Autosomal Recessive 3 Spondylocostal Dysostosis 3 Autosomal Recessive Spondylocostal Dysostosis 3 Doid:0112361 Dysostosis, Spondylocostal, Autosomal Recessive, Type 3 Jarcho-Levin Syndrome
Noonan Syndrome 1	Noonan Syndrome NS1 Male Turner Syndrome Female Pseudo-Turner Syndrome Turner Phenotype With Normal Karyotype Noonan Syndrome With Pigmented Villonodular Synovitis Turner'S Phenotype, Karyotype Normal Familial Turner Syndrome Noonan'S Syndrome Noonan-Ehmke Syndrome Ns Pseudo-Ullrich-Turner Syndrome Turner Syndrome In Female With X Chromosome Turner-Like Syndrome Ullrich-Noonan Syndrome Noonan-Like/Multiple Giant Cell Lesion Syndrome Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions Pterygium Colli Syndrome Noonan Syndrome, Type 1 Turner Syndrome, Male
Primary Hyperoxaluria	Hyperoxaluria Hyperoxaluria, Primary Oxalosis Primary Oxalosis Congenital Oxaluria D-Glycerate Dehydrogenase Deficiency Glyceric Aciduria Glycolic Aciduria Hepatic Agt Deficiency Oxaluria, Primary Peroxisomal Alanine:Glyoxylate Aminotransferase Deficiency Primary Oxaluria Hyperoxaluria Primary Primary Hyperoxaluria Type 2 Primary Hyperoxaluria, Type I
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias
3-Methylglutaconic Aciduria, Type Iii	Optic Atrophy 3-Methylglutaconic Aciduria Type 3 Costeff Syndrome Mga3 Costeff Optic Atrophy Syndrome Optic Atrophy Plus Syndrome Infantile Optic Atrophy With Chorea And Spastic Paraplegia 3-Methylglutaconic Aciduria Type Iii Autosomal Recessive Optic Atrophy Plus Syndrome Autosomal Recessive Optic Atrophy Type 3 Opa3 Defect MGCA3 Mga, Type Iii Iraqi Jewish Optic Atrophy Plus Mga Type Iii Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia Iraqi-Jewish 'Optic Atrophy Plus' Optic Atrophy 3, Autosomal Recessive Opa3, Autosomal Recessive Opa3-Related 3-Methylglutaconic Aciduria Iraqi-Jewish Optic Atrophy Plus Atrophy Of Optic Disc 3-Alpha Methylglutaconic Aciduria Type Iii Optic Atrophy 3 Optic Atrophy Infantile With Chorea And Spastic Paraplegia Autosomal Recessive Opa3 Autosomal Recessive Optic Atrophy 3 3-Methylglutaconic Aciduria 3 3-Alpha-Methylglutaconic Aciduria Type 3 Optic Atrophy 3 Autosomal Recessive Atrophy, Optic Atrophy, Optic, Plus Syndrome Optic Nerve Atrophy Primary Optic Atrophy Oa - [Optic Atrophy] Second Cranial Nerve Atrophy Second Cranium Nerve Atrophy
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Cerebellar Disease	Cerebellar Diseases Cerebellar Dysfunction Cerebellar Abnormality Cerebellar Disorders
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07606	LGALS4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18869	Lgals4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25360	Lgals4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LGALS4	MGD	MGI:107536
Canis familiaris	LGALS4	VGNC	VGNC:42649
Felis catus	LGALS4	VGNC	VGNC:68040
Rattus norvegicus	LGALS4	RGD	RGD:3003
Bos taurus	LGALS4	VGNC	VGNC:30854
Macaca mulatta	LGALS4	VGNC	VGNC:74257
Others	LGALS4	NCBI