CASP2 - caspase 2 Gene

Also Known as ICH1; NEDD2; CASP-2; NEDD-2; PPP1R57

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 835

About CASP2

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:143,288,351-143,307,696 (from NCBI)

This gene has 7 transcripts (splice variants), 215 orthologues, 16 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 14.7), lymph node (RPKM 11.6) and 25 other tissues.

Summary

This gene encodes a member of the cysteine-aspartic acid protease (Caspase) family. Caspases mediate cellular Apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

CASP2 Products (4)

mRNA	Protein	Name
NM_032982.4	NP_116764.2	caspase-2 isoform 1 preproprotein
NM_032984.2
NM_001224.5	NP_001215.1	caspase-2 isoform 2
NM_032983.4	NP_116765.2	caspase-2 isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	9044836	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	22531785	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	8985253	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	9044836	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IMP IMP: Inferred from mutant phenotype	21726810	GOA
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	19593445	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	10980123	GOA
involved in protein processing	IDA IDA: Inferred from direct assay	9044836	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of endopeptidase complex	IPI IPI: Inferred from physical interaction	15073321	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CASP2 Protein Structure

CARD

Peptidase_C14

0
100
200
300
400
452 a.a.

Protein Preferred Names	Protein Names
caspase-2	caspase 2 apoptosis-related cysteine peptidase neural precursor cell expressed developmentally down-regulated protein 2 protease ICH-1 protein phosphatase 1, regulatory subunit 57

CASP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CASP2	P42575	BAG4	Homo sapiens	O95429	Y2H Prey Pooling	32296183
Intra	CASP2	P42575	BAG4	Homo sapiens	O95429	Y2H Array	32296183
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Validated Y2H	25416956
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Affinity Chrom	15073321
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	CoIP	8985253
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Validated Y2H	32296183
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Y2H Array	25416956
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Anti Bait CoIP	16652156
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	MAPPIT	31467278
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	BRET	37398436
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Complementation	31467278
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Validated Y2H	27107012
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Y2H Array	31467278
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Lumier	37398436
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Anti Tag CoIP	15073321
Intra	CASP2	P42575	CRADD	Homo sapiens	P78560	Y2H Prey Pooling	25416956
Intra	CASP2	P42575	CASP2	Homo sapiens	P42575-1	Anti Tag CoIP	11156409

Cross: Cross-species interaction Intra: Intraspecies interaction

CASP2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83027	Cleaved-Caspase 2 Antibody (YA2772)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Lung Cancer Susceptibility 3	Lung Adenocarcinoma Adenocarcinoma Of Lung LNCR3 Adenocarcinoma Of Lung, Susceptibility To Bronchogenic Lung Adenocarcinoma Nonsmall Cell Adenocarcinoma Adenocarcinoma Lung Lung Adenocarcinomas Non-Small Cell Adenocarcinoma
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Temporal Lobe Epilepsy	Epilepsy, Temporal Lobe Epilepsy Temporal Lobe
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Nonarteritic Anterior Ischemic Optic Neuropathy	Anterior Ischemic Optic Neuropathy Nonarteritic Anterior Ischemic Optic Neuropathy, Susceptibility To NAION Non-Arteritic Anterior Ischemic Optic Neuropathy Ischemic Optic Neuropathy Aion Optic Neuropathy, Ischemic Naion, Susceptibility To Optic Neuropathy, Anterior Ischemic Optic Neuropathy, Anterior Ischemic, Susceptibility To Non-Arteritic Anterior Ischaemic Optic Neuropathy Nonarteritic Anterior Ischaemic Optic Neuropathy Neuropathy, Optic, Ischemic, Nonarteritic Anterior, Susceptibility To Ion - [Ischemic Optic Neuropathy] Neuropathic Ischaemia Of N.Opticus Ischaemic Neuropathy Of Optic Nerve
Bladder Transitional Cell Papilloma	Bladder Papilloma Transitional Cell Papilloma Of Bladder Urinary Bladder Urothelial Papilloma Urothelial Papilloma Bladder Urothelial Papilloma
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0227	SHU 9119		99.83%	Unkown
HY-P1208	PG-931	Agonist	99.60%	Unkown
HY-RS01949	CASP2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS01950	Casp2 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS01951	Casp2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CASP2	VGNC	VGNC:60381
Macaca mulatta	CASP2	VGNC	VGNC:80804
Bos taurus	CASP2	VGNC	VGNC:26780
Canis familiaris	CASP2	VGNC	VGNC:38733
Rattus norvegicus	CASP2	RGD	RGD:69274
Mus musculus	CASP2	MGD	MGI:97295
Others	CASP2	NCBI