GPI-1485
Based on 2 publication(s) in Google Scholar
GPI-1485 (GM1485), a nonimmunosuppressive immunophilin ligand, promotes neurofunctional improvement and neural regeneration following stroke.
For research use only. We do not sell to patients.
- Purity: 99.56%
- CAS No.: 186268-78-0
- Formula: C12H19NO4
- Molecular Weight:241.28
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) GPI-1485
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Biological Activity
GPI-1485 (GM1485; 100 μM) induces cellular reprogramming and neural cell induction in normal human dermal fibroblasts (NHDF)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Normal human dermal fibroblasts (NHDF)[1]
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Concentration:100 μM
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Incubation Time:
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Result:Induced cellular reprogramming and neural cell induction.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult male Wistar rats, weighing 250-300 g[1]
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Dosage:5 mg/kg
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Administration:Intraperitoneal injection; daily; for a total of 42 days
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Result:Administration improved neurological function and is consistent with an upregulation of endogenous neurogenesis following stroke in rats.
Chemical Information
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CAS No. 186268-78-0
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Appearance Solid
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Molecular Weight 241.28
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Formula C12H19NO4
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Color White to light yellow
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SMILES
O=C(O)[C@H]1N(C(C(C(C)(C)CC)=O)=O)CCC1
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Synonyms
GM1485
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
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Nat Cell Biol
ER-to-Golgi trafficking through a dynamic intermediate cis-Golgi tubular network in Arabidopsis. [Abstract]2025 Mar;27(3):424-437. PMID: 40000850 -
Solvent & Solubility
DMSO : 100 mg/mL (414.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (8.62 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (8.62 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.1446 mL | 20.7228 mL | 41.4456 mL | 103.6141 mL |
| 5 mM | 0.8289 mL | 4.1446 mL | 8.2891 mL | 20.7228 mL | |
| 10 mM | 0.4145 mL | 2.0723 mL | 4.1446 mL | 10.3614 mL | |
| 15 mM | 0.2763 mL | 1.3815 mL | 2.7630 mL | 6.9076 mL | |
| 20 mM | 0.2072 mL | 1.0361 mL | 2.0723 mL | 5.1807 mL | |
| 25 mM | 0.1658 mL | 0.8289 mL | 1.6578 mL | 4.1446 mL | |
| 30 mM | 0.1382 mL | 0.6908 mL | 1.3815 mL | 3.4538 mL | |
| 40 mM | 0.1036 mL | 0.5181 mL | 1.0361 mL | 2.5904 mL | |
| 50 mM | 0.0829 mL | 0.4145 mL | 0.8289 mL | 2.0723 mL | |
| 60 mM | 0.0691 mL | 0.3454 mL | 0.6908 mL | 1.7269 mL | |
| 80 mM | 0.0518 mL | 0.2590 mL | 0.5181 mL | 1.2952 mL | |
| 100 mM | 0.0414 mL | 0.2072 mL | 0.4145 mL | 1.0361 mL |
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