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Cat. No.: HY-N10404

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Junceellolide C

Junceellolide C is a transcription inhibitor of cccDNA. Junceellolide C inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA with EC₅₀ values of 5.19, 3.52 μM respectively in HepAD38 cells. Junceellolide C is a potent anti-HBV agent.

For research use only. We do not sell to patients.

CAS No.: 121769-82-2
Formula: C₂₆H₃₃ClO₁₀
Molecular Weight:540.99

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

Junceellolide C Chemical Structure

CAS No.: 121769-82-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

EC50: 2.27 μM (HBV DNA replication), 3.52 μM (HBV RNA decrease) in HBeAg cells^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
BMDM	CC₅₀	>50 μM Compound: 31	Cytotoxicity against C57BL/6 mouse BMDM cells incubated for 48 hrs by MTT assay Cytotoxicity against C57BL/6 mouse BMDM cells incubated for 48 hrs by MTT assay	[PMID: 36446206]
HepG2	CC₅₀	>100 μM Compound: 27	Cytotoxicity against human HepG2 cells assessed as cell viability incubated for 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell viability incubated for 72 hrs by MTT assay	[PMID: 32690259]

In Vitro

Junceellolide C (10 μM; 72 hours) inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA in HepAD38 cells with EC₅₀ values of 2.27, 3.52 μM, respectively^[1].
Junceellolide C (10 μM; 8 days) can capable to inhibit HBV cccDNA replenishment and also to induce the existed HBV cccDNA degradation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HepAD38 cells
Concentration:

10 μM
Incubation Time:

72 h, 8 days
Result:

Inhibited cccDNA transcription.

Chemical Information

CAS No. 121769-82-2
Molecular Weight 540.99
Formula C₂₆H₃₃ClO₁₀
SMILES

C[C@@]12[C@]([C@@H]([C@]3([C@@]([C@H](C(/C=C\[C@@H]2OC(C)=O)=C)Cl)([H])OC([C@@H]3C)=O)O)OC(C)=O)([H])[C@]4(CC[C@@H]1OC(C)=O)CO4
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
- Animals
South China Sea gorgonian Dichotella gemmacea
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jiru Wu, et al. Briarane-type diterpenoids from a gorgonian coral Ellisella sp. with anti-HBV activities. Bioorg Chem. 2020 Dec;105:104423. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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