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Cat. No.: HY-182646

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NE-10133

NE-10133 is a I_SK and I_KS potassium channel (Potassium Channel) inhibitor. NE-10133 inhibits voltage-dependent and slowly activated delayed rectifier potassium currents. NE-10133 exhibits class III antiarrhythmic activity. NE-10133 is applicable for research related to arrhythmias.

For research use only. We do not sell to patients.

CAS No.: 149889-02-1
Formula: C₂₃H₃₀Cl₃N₅O₄
Molecular Weight:546.87

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NE-10133 Chemical Structure

CAS No.: 149889-02-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

NE-10133 potently inhibits rat I_SK channels expressed in Xenopus oocytes, with an EC₅₀ of 12 μM; at concentrations up to 20 μM, it exerts no effect on RBK1, RBK2 or RGK5 potassium channels^[2].
NE-10133 potently inhibits the I_Ks potassium current in guinea pig ventricular myocytes with an EC₅₀ of 11 μM, and its efficacy is comparable to its inhibitory effect on rat I_SK channels in Xenopus oocytes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 149889-02-1
Molecular Weight 546.87
Formula C₂₃H₃₀Cl₃N₅O₄
SMILES

O=C1N(CC(N1CCCN2CCN(CC2)CCO)=O)/N=C/C3=CC=C(C4=CC=C(Cl)C=C4)O3.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bao JJ, et al. Separation and quantitation of azimilide and its putative metabolites by capillary electrophoresis. J Chromatogr B Biomed Sci Appl. 1998;720(1-2):129-140. [Content Brief]

[2]. Busch AE, et al. The novel class III antiarrhythmics NE-10064 and NE-10133 inhibit IsK channels expressed in Xenopus oocytes and IKs in guinea pig cardiac myocytes. Biochem Biophys Res Commun. 1994;202(1):265-270. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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