ZLY28
Based on 1 Customer Validation
ZLY28 is the first-in-class intestinal restricted and orally active FXR and FABP1 dual modulator. ZLY28 also is a novel anti-NASH agent. ZLY28 can be used for the research of nonalcoholic steatohepatitis (NASH).
For research use only. We do not sell to patients.
- Purity: 99.95%
- CAS No.: 3004676-77-8
- Formula: C29H23Cl2NO4
- Molecular Weight:520.40
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Oxygen Sensing Compound Library
HY-L045
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Orally Active Compound Library
HY-L061
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Nuclear Receptor Compound Library
HY-L126
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Metabolic Enzyme Compound Library
HY-L146
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
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High-Throughput Bioactive Compound Library
HY-L205
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Metabolism/Protease Compound Library
HY-L012
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Anti-Aging Compound Library
HY-L034
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8 weeks old male C57BL/6 mice[1]
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Dosage:20 mg/kg
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Administration:Oral administration
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Result:Mainly distributed in the ileum with an ileum/plasma ratio of 104.1.
Significantly alleviated hepatic steatosis, lobular inflammation and ballooning.
Improved hepatic lipid homeostasis by inhibiting lipogenesis and promoting lipolysis.
Downregulated the gene expression levels.
Exhibited an acceptable safety profile with no acute toxicity.
Chemical Information
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CAS No. 3004676-77-8
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Appearance Solid
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Molecular Weight 520.40
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Formula C29H23Cl2NO4
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Color White to off-white
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SMILES
O=C(C1(C2=CC(C3=CC=C(OCC4=C(C5CC5)ON=C4C6=C(Cl)C=CC=C6Cl)C=C3)=CC=C2)CC1)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (192.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (9.61 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.9216 mL | 9.6080 mL | 19.2160 mL | 48.0400 mL |
| 5 mM | 0.3843 mL | 1.9216 mL | 3.8432 mL | 9.6080 mL | |
| 10 mM | 0.1922 mL | 0.9608 mL | 1.9216 mL | 4.8040 mL | |
| 15 mM | 0.1281 mL | 0.6405 mL | 1.2811 mL | 3.2027 mL | |
| 20 mM | 0.0961 mL | 0.4804 mL | 0.9608 mL | 2.4020 mL | |
| 25 mM | 0.0769 mL | 0.3843 mL | 0.7686 mL | 1.9216 mL | |
| 30 mM | 0.0641 mL | 0.3203 mL | 0.6405 mL | 1.6013 mL | |
| 40 mM | 0.0480 mL | 0.2402 mL | 0.4804 mL | 1.2010 mL | |
| 50 mM | 0.0384 mL | 0.1922 mL | 0.3843 mL | 0.9608 mL | |
| 60 mM | 0.0320 mL | 0.1601 mL | 0.3203 mL | 0.8007 mL | |
| 80 mM | 0.0240 mL | 0.1201 mL | 0.2402 mL | 0.6005 mL | |
| 100 mM | 0.0192 mL | 0.0961 mL | 0.1922 mL | 0.4804 mL |
ZLY28 Related Classifications
HY-149831 Related Classifications
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