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Cat. No.: HY-126324

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IV-23

IV-23 (Compound 20) is a potent Noxa mediated apoptosis inducer, and it is a promising anticancer agent with potential. IV-23 inhibits cell growths in vitro and in vivo, reduces colony formation, arrests cell cycle at M phase, and induces esophageal squamous cell carcinoma (ESCC).

For research use only. We do not sell to patients.

CAS No.: 2326007-49-0
Formula: C₁₈H₁₈BrNO₄
Molecular Weight:392.24

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

IV-23 Chemical Structure

CAS No.: 2326007-49-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	6.82 μM Compound: 9d	Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human A549 cells incubated for 48 hrs by CCK8 assay	[PMID: 33965530]
A549	IC₅₀	6.82 μM Compound: 9d	Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay	[PMID: 34022412]
ECa-109 cell line	IC₅₀	2.24 μM Compound: 9d	Antiproliferative activity against human Eca-109 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human Eca-109 cells incubated for 48 hrs by CCK8 assay	[PMID: 33965530]
ECa-109 cell line	IC₅₀	2.24 μM Compound: 9d	Antiproliferative activity against human Eca-109 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay Antiproliferative activity against human Eca-109 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay	[PMID: 34022412]
KYSE-30	IC₅₀	1.61 μM Compound: 9d	Antiproliferative activity against human KYSE-30 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human KYSE-30 cells incubated for 48 hrs by CCK8 assay	[PMID: 33965530]
KYSE-30	IC₅₀	1.61 μM Compound: 9d	Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay Antiproliferative activity against human KYSE-30 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay	[PMID: 34022412]
KYSE-450	IC₅₀	1.49 μM Compound: 9d	Antiproliferative activity against human KYSE-450 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human KYSE-450 cells incubated for 48 hrs by CCK8 assay	[PMID: 33965530]
KYSE-450	IC₅₀	1.49 μM Compound: 9d	Antiproliferative activity against human KYSE-450 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay Antiproliferative activity against human KYSE-450 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay	[PMID: 34022412]
KYSE-510	IC₅₀	2.08 μM Compound: 9d	Antiproliferative activity against human KYSE-510 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human KYSE-510 cells incubated for 48 hrs by CCK8 assay	[PMID: 33965530]
KYSE-510	IC₅₀	2.08 μM Compound: 9d	Antiproliferative activity against human KYSE-510 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay Antiproliferative activity against human KYSE-510 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay	[PMID: 34022412]
MGC-803	IC₅₀	1.84 μM Compound: 9d	Antiproliferative activity against human MGC-803 cells incubated for 48 hrs by CCK8 assay Antiproliferative activity against human MGC-803 cells incubated for 48 hrs by CCK8 assay	[PMID: 33965530]
MGC-803	IC₅₀	1.84 μM Compound: 9d	Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay Antiproliferative activity against human MGC-803 cells assessed as inhibition of cell proliferation measured after 48 hrs by CCK8 assay	[PMID: 34022412]

In Vitro

IV-23 (Compound 20) shows a strong inhibition against the ESCCs in a concentration depend manner, the IC₅₀ values against the Kyse30 and Kyse450 cell lines were all less than 2 μM, presented in a dose-dependent manner. IV-23 triggeres caspases related apoptosis in ESCC cells^[1].
IV-23 induces G2/M phase arrest^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2326007-49-0
Molecular Weight 392.24
Formula C₁₈H₁₈BrNO₄
SMILES

O=C(N1CCC2=C1C=CC(Br)=C2)C3=CC(OC)=C(OC)C(OC)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fu DJ, et al. Discovery of indoline derivatives that inhibit esophageal squamous cell carcinoma growth by Noxa mediated apoptosis. Bioorg Chem. 2019 Aug 10;92:103190. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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