1. Apoptosis
  2. Apoptosis
  3. IV-23

IV-23 

Cat. No.: HY-126324
Handling Instructions

IV-23 (Compound 20) is a potent Noxa mediated apoptosis inducer, and it is a promising anticancer agent with potential. IV-23 inhibits cell growths in vitro and in vivo, reduces colony formation, arrests cell cycle at M phase, and induces Noxa-dependent apoptosis in esophageal squamous cell carcinoma (ESCC).

For research use only. We do not sell to patients.

IV-23 Chemical Structure

IV-23 Chemical Structure

CAS No. : 2326007-49-0

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Description

IV-23 (Compound 20) is a potent Noxa mediated apoptosis inducer, and it is a promising anticancer agent with potential. IV-23 inhibits cell growths in vitro and in vivo, reduces colony formation, arrests cell cycle at M phase, and induces Noxa-dependent apoptosis in esophageal squamous cell carcinoma (ESCC)[1].

In Vitro

IV-23 (Compound 20) shows a strong inhibition against the ESCCs in a concentration depend manner, the IC50 values against the Kyse30 and Kyse450 cell lines were all less than 2 μM, presented in a dose-dependent manner. IV-23 triggeres caspases related apoptosis in ESCC cells[1].
IV-23 induces G2/M phase arrest[1].

Molecular Weight

392.24

Formula

C₁₈H₁₈BrNO₄

CAS No.

2326007-49-0

SMILES

O=C(N1CCC2=C1C=CC(Br)=C2)C3=CC(OC)=C(OC)C(OC)=C3

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IV-23
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