Doliroside A
Doliroside A is an Aβ42-binding agent with an IC50 of 26.57 μM for Aβ42. Doliroside A binds to Aβ42 nuclei and oligomers to form stable complexes, suppresses Aβ42 fibrillation, and redirects Aβ42 into off-pathway, amorphous oligomers. Doliroside A can be used for the research of alzheimer’s disease (ad).
For research use only. We do not sell to patients.
- CAS No.: 93078-67-2
- Formula: C37H58O11
- Molecular Weight:678.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Doliroside A (2.5-250 μM; up to 40 h) potently inhibits Aβ42 fibrillogenesis with an IC50 of 26.57 μM, showing concentration-dependent reduction of ThT fluorescence associated with Aβ42 fibril formation[1].
Doliroside A (125 μM; up to 30 h) suppresses the increase of β-sheet content in Aβ42 and inhibits the formation of insoluble β-sheet-rich fibrils during Aβ42 aggregation[1].
Doliroside A (125 μM; 24 h) alters Aβ42 aggregation morphology, redirecting the formation of fibrillar aggregates into amorphous oligomers[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 93078-67-2
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Molecular Weight 678.85
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Formula C37H58O11
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SMILES
C[C@]12[C@@](CC=C3[C@]2(CC[C@@]4([C@@]3([H])CC(C)(CC4)C)C(O)=O)C)([H])[C@@]5([C@@]([C@@](C)([C@H]([C@H](C5)O)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6O)O)O)CO)C(OC)=O)([H])CC1)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Doliroside A Related Classifications
HY-N17929 Related Classifications
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