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Cat. No.: HY-121802

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Dynarrestin

5 Cited Publications

Customer Review

Based on 5 publication(s) in Google Scholar

Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells.

For research use only. We do not sell to patients.

Purity: 98.18%
CAS No.: 2222768-84-3
Formula: C₂₂H₂₃F₂N₃O₂S
Molecular Weight:431.50

Storage:

4°C, protect from light

* The compound is unstable in solutions, freshly prepared is recommended.

Dynarrestin Chemical Structure

CAS No.: 2222768-84-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
Chemical Information
Publications (5)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Chemical Information

CAS No. 2222768-84-3
Appearance Solid
Molecular Weight 431.50
Formula C₂₂H₂₃F₂N₃O₂S
Color Light brown to brown
SMILES

O=C(C1=C(C2=CC=C(N(CC)CC)C=C2)N=C(NC3=CC=C(F)C=C3F)S1)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

* The compound is unstable in solutions, freshly prepared is recommended.

Publications (5)

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Adv Sci (Weinh)

Pericentrosomal Redistribution of the Endoplasmic Reticulum Ensures Organelle Symmetric Inheritance and Mitotic Progression. [Abstract]

2026 Jun 22:e76193. PMID: 42325213
Free Radic Biol Med

Targeted nuclear degranulation of neutrophils in the shock stage of severe burns drives rapid neutrophil extracellular trap release during infection to mediate acute lung injury. [Abstract]

2025 Dec 9:244:107-119. PMID: 41371002
Curr Biol

The chirality of the mitotic spindle provides a mechanical response to forces and depends on microtubule motors and augmin. [Abstract]

2022 Jun 6;32(11):2480-2493.e6. PMID: 35537456
J Cell Biol

Septin-coated microtubules promote maturation of multivesicular bodies by inhibiting their motility. [Abstract]

2024 Aug 5;223(8):e202308049. PMID: 38668767
Res Sq

2025 Dec 9.

Solvent & Solubility

In Vitro:

DMSO : 83.33 mg/mL (193.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3175 mL

11.5875 mL

23.1750 mL

5 mM

0.4635 mL

2.3175 mL

4.6350 mL

10 mM

0.2317 mL

1.1587 mL

2.3175 mL

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 17% Solutol HS-15 in Saline

Solubility: 10 mg/mL (23.17 mM); Suspended solution; Need ultrasonic

Protocol 2

Add each solvent one by one: 0.5% CMC-Na/1% Tween-80 in Saline water

Solubility: 10 mg/mL (23.17 mM); Suspended solution; Need ultrasonic

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Höing S, et al. Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein. Cell Chem Biol. 2018 Apr 19;25(4):357-369.e6. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3175 mL	11.5875 mL	23.1750 mL	57.9374 mL
	5 mM	0.4635 mL	2.3175 mL	4.6350 mL	11.5875 mL
	10 mM	0.2317 mL	1.1587 mL	2.3175 mL	5.7937 mL
	15 mM	0.1545 mL	0.7725 mL	1.5450 mL	3.8625 mL
	20 mM	0.1159 mL	0.5794 mL	1.1587 mL	2.8969 mL
	25 mM	0.0927 mL	0.4635 mL	0.9270 mL	2.3175 mL
	30 mM	0.0772 mL	0.3862 mL	0.7725 mL	1.9312 mL
	40 mM	0.0579 mL	0.2897 mL	0.5794 mL	1.4484 mL
	50 mM	0.0463 mL	0.2317 mL	0.4635 mL	1.1587 mL
	60 mM	0.0386 mL	0.1931 mL	0.3862 mL	0.9656 mL
	80 mM	0.0290 mL	0.1448 mL	0.2897 mL	0.7242 mL
	100 mM	0.0232 mL	0.1159 mL	0.2317 mL	0.5794 mL

Keywords

MOQ

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100 mg

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Biological Activity
- Description
Chemical Information
Publications (5)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References

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Dynarrestin

MCE Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) Dynarrestin

Biological Activity

Chemical Information

Publications (5)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Dynarrestin

MCE Bioactive Compound Library

Publications Citing Use of MedChemExpress (MCE) Dynarrestin

Biological Activity

Chemical Information

Publications (5)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Dynarrestin Related Classifications

HY-121802 Related Classifications