EMD-C02602
EMD-C02602 is a GCN2-targeting agent with IC50 values of 0.023 μM, 4.52 μM, ＞ 10 μM and 0.048 μM for GCN2, PERK, HRland PKR, respectively.
For research use only. We do not sell to patients.
- Formula: C19H21F4N7O2S
- Molecular Weight:487.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
EMD-C02602 (0–10 μM, 72 h) exhibits a U-shaped viability response in MOLM-16 cells, , causing the most significant decrease in cell viability at intermediate concentrations (around 0.05 μM), while showing reduced inhibitory effects at both lower and higher concentrations[1].
EMD-C02602 (0.05-0.12 μM, 8 h) increases the expression of ATF4 [1].
EMD-C02602 (0.5-1.1 μM, 8 h) increases the expression of p-GCN2 while shows no effect on the expression of GCN2 [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 487.47
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Formula C19H21F4N7O2S
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SMILES
O=S(NC[C@@H]1CN(C2=NC=NC(C3=CN=C4C=CC(C(F)F)=NN43)=C2)C[C@H](C)C1(F)F)(C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EMD-C02602 Related Classifications
HY-175878 Related Classifications
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