ADO - 2-aminoethanethiol dioxygenase Gene

Also Known as C10orf22

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84890

About ADO

Cytogenetic location: 10q21.3 Genomic coordinates (GRCh38): 10:62,804,720-62,808,479 (from NCBI)

This gene has 1 transcript (splice variant) and 247 orthologues.

Summary

Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine (Dominy et al., 2007 [PubMed 17581819]).[supplied by OMIM, Mar 2008]

ADO Products (1)

mRNA Protein Name
NM_032804.6 NP_116193.2 2-aminoethanethiol dioxygenase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cysteamine dioxygenase activity IDA
IDA: Inferred from direct assay
31273118 GOA
enables cysteamine dioxygenase activity IMP
IMP: Inferred from mutant phenotype
17581819 GOA
enables iron ion binding IDA
IDA: Inferred from direct assay
34508780 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IDA
IDA: Inferred from direct assay
31273118 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADO Protein Structure

PCO_ADO

PCO_ADO: PCO_ADO (57 - 268)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

2-aminoethanethiol dioxygenase

  • 2-aminoethanethiol (cysteamine) dioxygenase

ADO Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ADO Q96SZ5 CAP2 Homo sapiens P40123
Y2H Prey Pooling
32296183
Intra
ADO Q96SZ5 CAP2 Homo sapiens P40123
Y2H Array
32296183
Intra
ADO Q96SZ5 DISC1 Homo sapiens Q9NRI5-2
Validated Y2H
32296183
Intra
ADO Q96SZ5 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
Intra
ADO Q96SZ5 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Ataxia, Sensory, 1, Autosomal Dominant

  • Autosomal Dominant Sensory Ataxia 1

  • SNAX1

  • Adsa

  • Ataxia, Sensory, Type 1, Autosomal Dominant

  • Ataxia, Sensory, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9921 Trastuzumab emtansine Inhibitor 99.74% Unkown
HY-P9921A Trastuzumab emtansine (solution) 98.27% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-103400 8-Chloroadenosine 99.75% Phase 2
HY-19842 GS-9667 Agonist 98.08% Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148327 AK-IN-1 Inhibitor 99.21% Unkown
HY-125927 8-Aminoadenosine 99.05% Unkown
HY-W101723 Boc-12-Ado-OH ≥97.0% Unkown
HY-134313 8-NH2-ATP / Unkown
HY-134313A 8-NH2-ATP tetrasodium 98.0% Unkown
HY-180424 SYAF080 Antagonist / Unkown
HY-RS00390 ADO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-123038 CVT-5440 Antagonist / Unkown
HY-123196 CVT-2759 Inhibitor / Unkown
HY-15903 ADOS / Unkown
HY-RS18889 Ado Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25380 Ado Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ADO VGNC VGNC:69675
Rattus norvegicus ADO RGD RGD:1308233
Canis familiaris ADO VGNC VGNC:37664
Bos taurus ADO VGNC VGNC:25685
Mus musculus ADO MGD MGI:2685083
Felis catus ADO VGNC VGNC:59647
Others ADO NCBI