SYAF080
SYAF080 is a human A₂B adenosine receptor (hA₂B AdoR) antagonist with a Ki of 23.6 nM and a KB of 25.2 nM. SYAF080no relevant inhibition of human CYP450 cytochromes. SYAF080 can be used for the research of inflammation, metabolic and cardiovascular disease.
For research use only. We do not sell to patients.
- CAS No.: 352692-70-7
- Formula: C12H14N2O3S
- Molecular Weight:266.32
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Adenosine Receptor Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
hA2B 23.6 nM (Ki) |
hA2B 25.2 nM (Kb) |
In Vitro
SYAF080 (Compound 21a) (10 µM) inhibits hA1, hA2A, hA2B and hA3 (Ki = 23.6 nM for hA2B; KB = 25.2 nM) and inhibits c-AMP production[1].
SYAF080 shows no relevant inhibition of human CYP450 cytochrome[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 352692-70-7
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Appearance Solid
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Molecular Weight 266.32
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Formula C12H14N2O3S
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Color White to off-white
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SMILES
O=C(OCC)C1=C(NC(=O)NC1C2=CSC=C2)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SYAF080 Related Classifications
HY-180424 Related Classifications
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