NBI-31772
Based on 3 publication(s) in Google Scholar
NBI-31772 is a non-selective IGFBP inhibitor (Ki=47 nM). NBI-31772 has neuroprotective effects and reduces infarct volume during cerebral ischemia. NBI-31772 can also restore or enhance proteoglycan synthesis in osteoarticular chondrocytes. In addition, NBI-31772 also increases the effect of IGF3 on zebrafish oocyte maturation.
For research use only. We do not sell to patients.
- Purity: 98.88%
- CAS No.: 374620-70-9
- Formula: C17H11NO7
- Molecular Weight:341.27
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) NBI-31772
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Biological Activity
NBI-31772 (0.1-10 µM; 24 h) stimulates the synthesis of IGF-1-dependent proteoglycans in human OA chondrocytes in a dose-dependent manner[3]. NBI-31772 (0.1-10 µM; 24 h) significantly stimulates the percentage of rabbit articular chondrocyte-associated proteoglycans in the presence of IGF-1 and IGFBP-3[3]. NBI-31772 (5-100 µM; 16 h) dose-dependently induces the maturation of zebrafish oocytes[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MCAO model rats[2]
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Dosage:5, 50 and 100 μg
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Administration:siv; Drug administration during ischemic episodes
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Result:Had similar effects on total lesion volume at the 50 and 100 μg doses.
Affected striatal lesion volume at the 50 μg dose.
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Animal Model:Intraluminal suture MCAO model rats[2]
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Dosage:50 μg
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Administration:i.v.; Administration 0, 1, 2, or 3 hours after MCAO
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Result:The greatest lesion reduction was observed when the drug was administered immediately after MCAO.
Chemical Information
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CAS No. 374620-70-9
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Appearance Solid
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Molecular Weight 341.27
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Formula C17H11NO7
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Color Light yellow to brown
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SMILES
O=C(C1=CC(O)=C(O)C=C1)C2=NC(C(O)=O)=CC3=C2C=C(O)C(O)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Publications (3)
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Journal Impact Factor
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Most Recent
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J Nanobiotechnology
Apoptotic vesicles from macrophages exacerbate periodontal bone resorption in periodontitis via delivering miR-143-3p targeting Igfbp5. [Abstract]2024 Oct 26;22(1):658. PMID: 39456001 -
Int J Biol Macromol
Unveiling the mechanistic link between peroxiredoxin inhibition and ferroptosis-like cell death induced by Dinaciclib in Entamoeba histolytica. [Abstract]2026 Mar:350:150992. PMID: 41713546 -
Solvent & Solubility
DMSO : 125 mg/mL (366.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Khawaja XZ. Development of a scintillation proximity assay for human insulin-like growth factor-binding protein 4 compatible with inhibitor high-throughput screening. Anal Biochem. 2007;366(1):80-86. [Content Brief]
[2]. Mackay K B, et al. Neuroprotective effects of insulin-like growth factor-binding protein ligand inhibitors in vitro and in vivo[J]. Journal of Cerebral Blood Flow & Metabolism, 2003, 23(10): 1160-1167. [Content Brief]
[3]. De Ceuninck F, et al. Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes[J]. Arthritis Res Ther, 2004, 6: 1-11. [Content Brief]
[4]. Li J, et al. Insulin-like growth factor binding proteins inhibit oocyte maturation of zebrafish[J]. General and Comparative Endocrinology, 2019, 281: 83-90. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9302 mL | 14.6512 mL | 29.3023 mL | 73.2558 mL |
| 5 mM | 0.5860 mL | 2.9302 mL | 5.8605 mL | 14.6512 mL | |
| 10 mM | 0.2930 mL | 1.4651 mL | 2.9302 mL | 7.3256 mL | |
| 15 mM | 0.1953 mL | 0.9767 mL | 1.9535 mL | 4.8837 mL | |
| 20 mM | 0.1465 mL | 0.7326 mL | 1.4651 mL | 3.6628 mL | |
| 25 mM | 0.1172 mL | 0.5860 mL | 1.1721 mL | 2.9302 mL | |
| 30 mM | 0.0977 mL | 0.4884 mL | 0.9767 mL | 2.4419 mL | |
| 40 mM | 0.0733 mL | 0.3663 mL | 0.7326 mL | 1.8314 mL | |
| 50 mM | 0.0586 mL | 0.2930 mL | 0.5860 mL | 1.4651 mL | |
| 60 mM | 0.0488 mL | 0.2442 mL | 0.4884 mL | 1.2209 mL | |
| 80 mM | 0.0366 mL | 0.1831 mL | 0.3663 mL | 0.9157 mL | |
| 100 mM | 0.0293 mL | 0.1465 mL | 0.2930 mL | 0.7326 mL |
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