PDM11
Based on 1 Customer Validation
PDM11 is a derivative of antioxidant resveratrol. PDM11 do not exhibit any significant protective effect against oxidation of linoleate micelles initiated by radiolysis-generated hydroxyl radicals. PDM11 is inactive in resveratrol activity assays.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 1032508-03-4
- Formula: C16H15ClO2
- Molecular Weight:274.74
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Antioxidant Compound Library
HY-L037
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Phosphatase Inhibitor Library
HY-L081
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Metabolic Enzyme Compound Library
HY-L146
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Radioprotector Library
HY-L178
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Anti-Fibrosis Compound Library
HY-L185
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Caco-2 | IC50 |
>10 μM
Compound: 19
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Cytotoxicity against human Caco-2 cells after 3 days by [3H]thymidine incorporation assay
Cytotoxicity against human Caco-2 cells after 3 days by [3H]thymidine incorporation assay
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[PMID: 20627379] |
| HT-29 | IC50 |
>10 μM
Compound: 19
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Cytotoxicity against human HT-29 cells after 3 days by [3H]thymidine incorporation assay
Cytotoxicity against human HT-29 cells after 3 days by [3H]thymidine incorporation assay
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[PMID: 20627379] |
| RAW264.7 | IC50 |
>50 μM
Compound: 6
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Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of NO release
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of NO release
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[PMID: 37852423] |
Chemical Information
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CAS No. 1032508-03-4
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Appearance Solid
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Molecular Weight 274.74
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Formula C16H15ClO2
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Color White to off-white
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SMILES
ClC1=CC=C(/C=C/C2=CC(OC)=CC(OC)=C2)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (181.99 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Kondratyuk TP, et al. Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity. Mol Nutr Food Res. 2011;55(8):1249-1265. [Content Brief]
[2]. Rhayem Y, et al. Chain-breaking activity of resveratrol and piceatannol in a linoleate micellar model. Chem Phys Lipids. 2008;155(1):48-56. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6398 mL | 18.1990 mL | 36.3981 mL | 90.9951 mL |
| 5 mM | 0.7280 mL | 3.6398 mL | 7.2796 mL | 18.1990 mL | |
| 10 mM | 0.3640 mL | 1.8199 mL | 3.6398 mL | 9.0995 mL | |
| 15 mM | 0.2427 mL | 1.2133 mL | 2.4265 mL | 6.0663 mL | |
| 20 mM | 0.1820 mL | 0.9100 mL | 1.8199 mL | 4.5498 mL | |
| 25 mM | 0.1456 mL | 0.7280 mL | 1.4559 mL | 3.6398 mL | |
| 30 mM | 0.1213 mL | 0.6066 mL | 1.2133 mL | 3.0332 mL | |
| 40 mM | 0.0910 mL | 0.4550 mL | 0.9100 mL | 2.2749 mL | |
| 50 mM | 0.0728 mL | 0.3640 mL | 0.7280 mL | 1.8199 mL | |
| 60 mM | 0.0607 mL | 0.3033 mL | 0.6066 mL | 1.5166 mL | |
| 80 mM | 0.0455 mL | 0.2275 mL | 0.4550 mL | 1.1374 mL | |
| 100 mM | 0.0364 mL | 0.1820 mL | 0.3640 mL | 0.9100 mL |
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