Cat. No.: HY-19355

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Rocagloic acid

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

Rocagloic acid is a racaglamide derivative isolated from the fruits of Aglaia elliptifolia with potent cytotoxicity.

For research use only. We do not sell to patients.

Purity: 97.08%
CAS No.: 190385-15-0
Formula: C₂₇H₂₆O₈
Molecular Weight:478.49

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Rocagloic acid Chemical Structure

CAS No.: 190385-15-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Rocagloic acid is a racaglamide derivative isolated from the fruits of Aglaia elliptifolia with potent cytotoxicity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	ED₅₀	0.00074 μg/mL Compound: 1	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 11170675]
A549	ED₅₀	0.74 ng/mL Compound: 1	Cytotoxicity against human A549 cells Cytotoxicity against human A549 cells	[PMID: 11170675]
Col2	ED₅₀	209 nM Compound: 3	Cytotoxicity against human Col2 cells Cytotoxicity against human Col2 cells	[PMID: 15043407]
HL-60	ED₅₀	0.00084 μg/mL Compound: 1	Cytotoxicity against human HL60 cells Cytotoxicity against human HL60 cells	[PMID: 11170675]
HL-60	ED₅₀	0.84 ng/mL Compound: 1	Cytotoxicity against human HL60 cells Cytotoxicity against human HL60 cells	[PMID: 11170675]
HT-29	ED₅₀	0.00084 μg/mL Compound: 1	Cytotoxicity against human HT-29 cells Cytotoxicity against human HT-29 cells	[PMID: 11170675]
HT-29	ED₅₀	0.84 ng/mL Compound: 1	Cytotoxicity against human HT-29 cells Cytotoxicity against human HT-29 cells	[PMID: 11170675]
HUVEC	ED₅₀	209 nM Compound: 3	Cytotoxicity against HUVEC Cytotoxicity against HUVEC	[PMID: 15043407]
KB	ED₅₀	0.0023 μg/mL Compound: 1	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 11170675]
KB	ED₅₀	204 nM Compound: 3	Cytotoxicity against human KB cells Cytotoxicity against human KB cells	[PMID: 15043407]
LNCaP	ED₅₀	104 nM Compound: 3	Cytotoxicity against human LNCAP cells Cytotoxicity against human LNCAP cells	[PMID: 15043407]
Lu1	ED₅₀	63 nM Compound: 3	Cytotoxicity against human Lu1 cells Cytotoxicity against human Lu1 cells	[PMID: 15043407]
P388	ED₅₀	0.0012 μg/mL Compound: 1	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 11170675]
TERT-RPE1	ED₅₀	209 nM Compound: 3	Cytotoxicity against human telomerase reverse transcriptase expressing human RPE1 cells Cytotoxicity against human telomerase reverse transcriptase expressing human RPE1 cells	[PMID: 15043407]

In Vitro

Rocagloic acid shows selective cytotoxicity against NCI-H187 cell line with an ED₅₀ of 0.036 ng/mL, and is inactive against oral human epidermoid carcinoma (KB) and human breast cancer (BC) cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 190385-15-0
Appearance Solid
Molecular Weight 478.49
Formula C₂₇H₂₆O₈
Color Off-white to light yellow
SMILES

O=C([C@H]([C@H]1C2=CC=CC=C2)[C@@H](O)[C@]3(O)[C@@]1(C4=CC=C(OC)C=C4)OC5=CC(OC)=CC(OC)=C35)O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (1)

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Journal Impact Factor

bioRxiv

Programmable translational inhibition by a molecular glue-oligonucleotide conjugate. [Abstract]

2025 Jul 16:2025.07.15.664547. PMID: 40791481

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (208.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.0899 mL

10.4495 mL

20.8991 mL

5 mM

0.4180 mL

2.0899 mL

4.1798 mL

10 mM

0.2090 mL

1.0450 mL

2.0899 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 5 mg/mL (10.45 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 5 mg/mL (10.45 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 5 mg/mL (10.45 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Parinuch Chumkaew, et al. Potent Cytotoxic Rocaglamide Derivatives From the Fruits of Amoora Cucullata. Chem Pharm Bull (Tokyo). 2006 Sep;54(9):1344-6. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.0899 mL	10.4495 mL	20.8991 mL	52.2477 mL
	5 mM	0.4180 mL	2.0899 mL	4.1798 mL	10.4495 mL
	10 mM	0.2090 mL	1.0450 mL	2.0899 mL	5.2248 mL
	15 mM	0.1393 mL	0.6966 mL	1.3933 mL	3.4832 mL
	20 mM	0.1045 mL	0.5225 mL	1.0450 mL	2.6124 mL
	25 mM	0.0836 mL	0.4180 mL	0.8360 mL	2.0899 mL
	30 mM	0.0697 mL	0.3483 mL	0.6966 mL	1.7416 mL
	40 mM	0.0522 mL	0.2612 mL	0.5225 mL	1.3062 mL
	50 mM	0.0418 mL	0.2090 mL	0.4180 mL	1.0450 mL
	60 mM	0.0348 mL	0.1742 mL	0.3483 mL	0.8708 mL
	80 mM	0.0261 mL	0.1306 mL	0.2612 mL	0.6531 mL
	100 mM	0.0209 mL	0.1045 mL	0.2090 mL	0.5225 mL

Keywords

Rocagloic acid

1 Cited Publications

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Rocagloic acid

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Publications Citing Use of MedChemExpress (MCE) Rocagloic acid

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Rocagloic acid

Natural Product Library

Anti-Cancer Compound Library

Traditional Chinese Medicine Active Compound Library

Anti-Breast Cancer Compound Library

Anti-Cancer Natural Product Library

Plant-Sourced Natural Product Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

RO5 Drug-like Natural Product Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Publications Citing Use of MedChemExpress (MCE) Rocagloic acid

Biological Activity

Chemical Information

Publications (1)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Rocagloic acid Related Classifications

Cat. No.: HY-19355