SDSSD
Based on 1 Customer Validation
SDSSD is an osteoblast-targeting peptide. SDSSD selectively binds to periostin on osteoblasts and mediates targeted delivery to these cells. SDSSD can endow calcium phosphate nanocomposites with bone-targeting properties, and these materials exhibit osteointegrative capacity in both in vitro and in vivo models. When conjugated with polyurethane nanomicelles, SDSSD enables targeted delivery of siRNA/microRNA to osteoblasts.
For research use only. We do not sell to patients.
- Purity: 99.60%
- CAS No.: 1927877-75-5
- Formula: C17H27N5O13
- Molecular Weight:509.42
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Peptide Library
HY-L105
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Osteogenesis Compound Library
HY-L131
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Peptide Compound Library
HY-L105S
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Bioactive Compound Library
HY-L001
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
SDSSD colocalizes with periostin in murine MC3T3-E1 clone 4 osteoblasts and human hFOB 1.19 osteoblasts[2].
SDSSD reduces the subsequent binding of FITC-labeled SDSSD peptide to periostin in mouse MC3T3-E1 clone 4 osteoblasts and human hFOB 1.19 osteoblasts[2].
SDSSD−PU efficiently delivers FAM-labeled siRNA to murine MC3T3-E1 clone 4 osteoblasts and human hFOB 1.19 osteoblasts, and the uptake process depends on periostin binding[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
SDSSD-modified polyurethane nanomicelles delivering GFP siRNA (10 mg/kg; tail vein injection) selectively reduce GFP mRNA and protein levels in bone tissue and isolated osteoblasts of GFP transgenic mice, demonstrating targeted gene knockdown efficacy[2].
SDSSD-modified polyurethane nanomicelles (10 mg/kg; tail vein injection) selectively deliver siRNA to bone tissues and mature osteoblasts in healthy mice, with no detectable in vivo toxicity or inflammatory response[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1927877-75-5
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Appearance Solid
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Molecular Weight 509.42
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Formula C17H27N5O13
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Color White to off-white
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Sequence
Ser-Asp-Ser-Ser-Asp
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Sequence Shortening
SDSSD
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (196.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Pan Z, et al. Periostin-targeted SDSSD peptide decorated calcium phosphate nanocomposites incorporation with simvastatin for osteoporosis treatment. Nanotechnology. 2023;35(7):10.1088/1361-6528/ad0dc9. Published 2023 Dec 1. [Content Brief]
[2]. Sun Y, et al. Osteoblast-Targeting-Peptide Modified Nanoparticle for siRNA/microRNA Delivery. ACS Nano. 2016;10(6):5759-5768. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9630 mL | 9.8151 mL | 19.6302 mL | 49.0754 mL |
| 5 mM | 0.3926 mL | 1.9630 mL | 3.9260 mL | 9.8151 mL | |
| 10 mM | 0.1963 mL | 0.9815 mL | 1.9630 mL | 4.9075 mL | |
| 15 mM | 0.1309 mL | 0.6543 mL | 1.3087 mL | 3.2717 mL | |
| 20 mM | 0.0982 mL | 0.4908 mL | 0.9815 mL | 2.4538 mL | |
| 25 mM | 0.0785 mL | 0.3926 mL | 0.7852 mL | 1.9630 mL | |
| 30 mM | 0.0654 mL | 0.3272 mL | 0.6543 mL | 1.6358 mL | |
| 40 mM | 0.0491 mL | 0.2454 mL | 0.4908 mL | 1.2269 mL | |
| 50 mM | 0.0393 mL | 0.1963 mL | 0.3926 mL | 0.9815 mL | |
| 60 mM | 0.0327 mL | 0.1636 mL | 0.3272 mL | 0.8179 mL | |
| 80 mM | 0.0245 mL | 0.1227 mL | 0.2454 mL | 0.6134 mL | |
| 100 mM | 0.0196 mL | 0.0982 mL | 0.1963 mL | 0.4908 mL |
SDSSD Related Classifications
HY-P11070 Related Classifications
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