Tinoridine
Based on 1 publication(s) in Google Scholar
Tinoridine (Y-3642) is an orally active non-steroidal anti-inflammatory agent with potent antiperoxidative ability and radical scavenger activity. Tinoridine acts function by inhibiting COX enzyme, involves in hepatotoxicity inhibition. .
For research use only. We do not sell to patients.
- Purity : 99.00%
- CAS No.: 24237-54-5
- Formula: C17H20N2O2S
- Molecular Weight:316.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Tinoridine
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Biological Activity
Description
In Vitro
Tinoridine (10-100 μM) exerts effect on stability of rat liver and kidney lysosomes, and liver parenchymal cells[3].
Tinoridine (1, 10, and 100 μM; 30 min) inhibits spontaneous release of acid phosphatase from liver lymomoses in vitro[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Tinoridine (100 mg/kg; i.p.; single dose) protects the stability of rat liver and kidney lysosomes in vivo[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (180-220 g)[2]
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Dosage:100 mg/kg
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Administration:Oral gavage; single dose; 1 hour before CCl4 (i.p.; 0.25 mL/kg) treatment
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Result:Inhibited the CCl4-induced enzyme activities increase of serum glutamic-oxaloacetic transaminase and glutamic-pyruvic transaminase, and also rescued the liver microsomal cytochrome P-450 and glucose-6-phosphatase activities.
Chemical Information
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CAS No. 24237-54-5
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Appearance Solid
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Molecular Weight 316.42
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Formula C17H20N2O2S
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Color Light yellow to yellow
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SMILES
NC(SC1=C2CCN(CC3=CC=CC=C3)C1)=C2C(OCC)=O
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Synonyms
Y-3642
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Free Radic Biol Med
Screening of NSAIDs library identifies Tinoridine as a novel ferroptosis inhibitor for potential intervertebral disc degeneration therapy. [Abstract]2024 May 26:221:245-256. PMID: 38806104
Solvent & Solubility
In Vitro:
DMSO : 125 mg/mL (395.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. da Cruz RMD, et al. Thiophene-Based Compounds with Potential Anti-Inflammatory Activity. Pharmaceuticals (Basel). 2021 Jul 19;14(7):692. [Content Brief]
[2]. Yasuda H, et al. The protective effect of tinoridine against carbon tetrachloride hepatotoxicity. Toxicol Appl Pharmacol. 1980 Mar 15;52(3):407-13. [Content Brief]
[3]. Goto K, et al. Effect of tinoridine on stability of rat liver and kidney lysosomes, and liver parenchymal cells. Biochem Pharmacol. 1977 Jan 1;26(1):11-8. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1604 mL | 15.8018 mL | 31.6036 mL | 79.0089 mL |
| 5 mM | 0.6321 mL | 3.1604 mL | 6.3207 mL | 15.8018 mL | |
| 10 mM | 0.3160 mL | 1.5802 mL | 3.1604 mL | 7.9009 mL | |
| 15 mM | 0.2107 mL | 1.0535 mL | 2.1069 mL | 5.2673 mL | |
| 20 mM | 0.1580 mL | 0.7901 mL | 1.5802 mL | 3.9504 mL | |
| 25 mM | 0.1264 mL | 0.6321 mL | 1.2641 mL | 3.1604 mL | |
| 30 mM | 0.1053 mL | 0.5267 mL | 1.0535 mL | 2.6336 mL | |
| 40 mM | 0.0790 mL | 0.3950 mL | 0.7901 mL | 1.9752 mL | |
| 50 mM | 0.0632 mL | 0.3160 mL | 0.6321 mL | 1.5802 mL | |
| 60 mM | 0.0527 mL | 0.2634 mL | 0.5267 mL | 1.3168 mL | |
| 80 mM | 0.0395 mL | 0.1975 mL | 0.3950 mL | 0.9876 mL | |
| 100 mM | 0.0316 mL | 0.1580 mL | 0.3160 mL | 0.7901 mL |
Tinoridine Related Classifications
HY-W032848 Related Classifications
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