2-MeS-ATP
2-MeS-ATP (2-Methylthio-ATP) is an analog of adenosine nucleotides and acts as a P2Y purinergic receptor agonist specific for adenosine nucleotide activation. 2-MeS-ATP is also able to inhibit the release of toxic mediators from macrophages stimulated by endotoxin (LPS). 2-MeS-ATP can be used in the study of endotoxin shock and inflammatory diseases.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 43170-89-4
- 分子式: C11H18N5O13P3S
- 分子量:553.27
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
P2Y Receptor アイソフォーム固有の製品をすべて表示
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
1 nM
Compound: 2
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Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cells
Concentration required for calcium mobilization at rat purinergic 2Y1 receptor expressed in HEK 293 cells
|
[PMID: 15317453] |
| Oocyte | EC50 |
1500 nM
Compound: 2-MeSATP
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Antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytes
Antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytes
|
[PMID: 12213051] |
| Oocyte | EC50 |
7400 nM
Compound: 2-MeSATP
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Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 30 uM, expressed in Xenopus oocytes
Antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) at 30 uM, expressed in Xenopus oocytes
|
[PMID: 12213051] |
化学情報
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CAS 番号 43170-89-4
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分子量 553.27
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分子式 C11H18N5O13P3S
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SMILES
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=C(SC)N=C3N)O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O
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別名
2-Methylthio-ATP
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)