3-Phenylphenol
Based on 1 Customer Validation
3-Phenylphenol is a secondary metabolite. 3-Phenylphenol can induce the hbp gene cluster in Pseudomonas sp. strain P1B16. 3-Phenylphenol can bind to the Sge1 transcription factor of Fusarium oxysporum f. sp. cubense and disrupt the function of virulence regulators. 3-Phenylphenol can be used in studies related to banana fusarium wilt.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.86%
- CAS 番号: 580-51-8
- 分子式: C12H10O
- 分子量:170.21
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保管条件:
RT, stored under nitrogen.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
25 μg/mL
Compound: 7
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Cytotoxicity against HEK293 cells assessed as reduction in cell growth after 3 days by MTT assay
Cytotoxicity against HEK293 cells assessed as reduction in cell growth after 3 days by MTT assay
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[PMID: 27259399] |
| HT-29 | IC50 |
28 μg/mL
Compound: 7
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Cytotoxicity against human HT-29 cells assessed as reduction in cell growth after 3 days by MTT assay
Cytotoxicity against human HT-29 cells assessed as reduction in cell growth after 3 days by MTT assay
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[PMID: 27259399] |
| MCF7 | IC50 |
27.4 μg/mL
Compound: 7
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Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 3 days by MTT assay
Cytotoxicity against human MCF7 cells assessed as reduction in cell growth after 3 days by MTT assay
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[PMID: 27259399] |
体外実験
3-Phenylphenol (0.1-100 mM; 72 h) induces the hbp operon in the Pseudomonas sp. P1B16/egfp biosensor strain[1].
3-Phenylphenol exhibits strong binding affinity to the Sge1 protein of Fusarium oxysporum f. sp. cubense, with a binding energy of -6.7 kcal/mol[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 580-51-8
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性状 Solid
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分子量 170.21
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分子式 C12H10O
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Color Off-white to light yellow
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SMILES
OC1=CC=CC(=C1)C=2C=CC=CC2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
RT, stored under nitrogen
In solvent -80°C 1 year -20°C 6 months
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (587.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
体内:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (14.69 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (14.69 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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データシート (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Suman J, et al. Transformation of hydroxylated polychlorinated biphenyls by bacterial 2-hydroxybiphenyl 3-monooxygenase. Chemosphere. 2024;349:140909. [Content Brief]
[2]. Sonkar P, et al. In silico profiling, docking analysis, and protein interactions of secondary metabolites in Musa spp. Against the SGE1 protein of Fusarium oxysporum f. sp. cubense. Comput Biol Chem. 2024;113:108230. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.8751 mL | 29.3755 mL | 58.7510 mL | 146.8774 mL |
| 5 mM | 1.1750 mL | 5.8751 mL | 11.7502 mL | 29.3755 mL | |
| 10 mM | 0.5875 mL | 2.9375 mL | 5.8751 mL | 14.6877 mL | |
| 15 mM | 0.3917 mL | 1.9584 mL | 3.9167 mL | 9.7918 mL | |
| 20 mM | 0.2938 mL | 1.4688 mL | 2.9375 mL | 7.3439 mL | |
| 25 mM | 0.2350 mL | 1.1750 mL | 2.3500 mL | 5.8751 mL | |
| 30 mM | 0.1958 mL | 0.9792 mL | 1.9584 mL | 4.8959 mL | |
| 40 mM | 0.1469 mL | 0.7344 mL | 1.4688 mL | 3.6719 mL | |
| 50 mM | 0.1175 mL | 0.5875 mL | 1.1750 mL | 2.9375 mL | |
| 60 mM | 0.0979 mL | 0.4896 mL | 0.9792 mL | 2.4480 mL | |
| 80 mM | 0.0734 mL | 0.3672 mL | 0.7344 mL | 1.8360 mL | |
| 100 mM | 0.0588 mL | 0.2938 mL | 0.5875 mL | 1.4688 mL |
3-Phenylphenol 関連分類
HY-W016983 関連分類
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