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製品番号: HY-114545

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5HPP-33

Name: 5HPP-33
Brand: MedChemExpress
SKU: HY-114545
Price: 132.00 USD
Availability: InStock
Rating: 5 (1 reviews)

5HPP-33 is an inhibitor for tubulin polymerization with IC₅₀ of 8.1 μM. 5HPP-33 inhibits the proliferation of leukemia cell and multiple myeloma cells with IC₅₀ of 1-10 μM, arrests the cell cycle at G2/M phase, and induces apoptosis.

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CAS 番号: 105624-86-0
分子式: C₂₀H₂₁NO₃
分子量:323.39

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

5HPP-33 構造式

CAS 番号: 105624-86-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
DU-145	IC₅₀	5.74 μM Compound: 5HPP-33	Antiproliferative activity against human DU145 cells assessed as growth inhibition by MTS assay Antiproliferative activity against human DU145 cells assessed as growth inhibition by MTS assay	[PMID: 24169233]
HeLa	IC₅₀	0.53 μM Compound: 5HPP-33	Inhibition of IL-1-alpha-induced NF-kappaB activation in HeLa cells assessed as blocking of p50/p65 nuclear translocation Inhibition of IL-1-alpha-induced NF-kappaB activation in HeLa cells assessed as blocking of p50/p65 nuclear translocation	[PMID: 17845850]
MDA-MB-231	IC₅₀	5.35 μM Compound: 5HPP-33	Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition by MTS assay Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition by MTS assay	[PMID: 24169233]
MOLT-4	IC₅₀	15 μg/mL Compound: 15	Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line	[PMID: 10098663]
MOLT-4	IC₅₀	21.3 μg/mL Compound: 15	Inhibitory activity against Dipeptidylpeptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line Inhibitory activity against Dipeptidylpeptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line	[PMID: 10098663]
MOLT-4	IC₅₀	46.4 μM Compound: 15	Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line Inhibitory activity against aminopeptidase N (APN) in human acute lymphoblastic leukemia MOLT-4 cell line	[PMID: 10098663]
MOLT-4	IC₅₀	65.9 μM Compound: 15	Inhibitory activity against Dipeptidylpeptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line Inhibitory activity against Dipeptidylpeptidase IV (DPP IV) in human acute lymphoblastic leukemia MOLT-4 cell line	[PMID: 10098663]
PC-3	IC₅₀	8.3 μM Compound: 5HPP-33	Antiproliferative activity against human PC3 cells assessed as growth inhibition by MTS assay Antiproliferative activity against human PC3 cells assessed as growth inhibition by MTS assay	[PMID: 24169233]
WI-38	IC₅₀	12.7 μg/mL Compound: 28	The cytotoxicity of the compounds assessed using human embryonic lung fibroblast WI-38 cells at (39 micro M) The cytotoxicity of the compounds assessed using human embryonic lung fibroblast WI-38 cells at (39 micro M)	[PMID: 9288167]

化学情報

CAS 番号 105624-86-0
分子量 323.39
分子式 C₂₀H₂₁NO₃
SMILES

O=C1C2=CC=C(C=C2C(N1C3=C(C(C)C)C=CC=C3C(C)C)=O)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Inatsuki S, et al. Tubulin-polymerization inhibitors derived from thalidomide. Bioorg Med Chem Lett. 2005 Jan 17;15(2):321-5. [Content Brief]

[2]. Iguchi T, et al. 5HPP-33, a Novel Tubulin-Polymerization Inhibitor Derived from Thalidomide, Directly Inhibits Proliferation and Induces Apoptosis of Human Multiple Myeloma Cells[J]. Blood, 2005, 106(11): 1586.

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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