Bemegride
Based on 1 Customer Validation
Bemegride (3-Ethyl-3-methylglutarimide) is a central nervous system stimulant and antidote for barbiturate poisoning.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.96%
- CAS 番号: 64-65-3
- 分子式: C8H13NO2
- 分子量:155.19
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-B1326R
Bemegride (Standard)
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HY-B0007
Baclofen
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HY-B0355
Ginkgolide A
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HY-B0009
Flumazenil
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HY-B0355R
Ginkgolide A (Standard)
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HY-103531
CGP52432
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HY-17030
Acamprosate calcium
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HY-17354
(R)-Baclofen
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HY-100809
Guvacine hydrochloride
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HY-N2338
Cholesterol myristate
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HY-B0007R
Baclofen (Standard)
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HY-B0009R
Flumazenil (Standard)
生物活性
GABAA receptor[1]
Bemegride has an antagonistic action on the GABAA receptor, suppressing both GABA- and pentobarbitone-evoked whole-cell currents to similar extents. [1] Long-term oral administration to the rat of barbitone, alone or together with the analeptics bemegride or pentylenetetrazol, show that the intensity of the withdrawal syndrome generally parallels the degree of associated CNS depression[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 64-65-3
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性状 Solid
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分子量 155.19
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分子式 C8H13NO2
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Color White to off-white
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SMILES
O=C(CC(C)(CC)C1)NC1=O
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別名
3-Ethyl-3-methylglutarimide; Bemegrid
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
DMSO : ≥ 32 mg/mL (206.20 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Mistry DK, et al. Actions of steroids and bemegride on the GABAA receptor of mouse spinal neurones in culture.Exp Physiol, 1990, 75(2),199-209. [Content Brief]
[2]. Arblaster CI, et al. Studies on the development of physical dependence on barbitone in the rat and rat atrium. Farmaco Sci. 1986 Jan, 41(1), 3-22. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 6.4437 mL | 32.2186 mL | 64.4371 mL | 161.0929 mL |
| 5 mM | 1.2887 mL | 6.4437 mL | 12.8874 mL | 32.2186 mL | |
| 10 mM | 0.6444 mL | 3.2219 mL | 6.4437 mL | 16.1093 mL | |
| 15 mM | 0.4296 mL | 2.1479 mL | 4.2958 mL | 10.7395 mL | |
| 20 mM | 0.3222 mL | 1.6109 mL | 3.2219 mL | 8.0546 mL | |
| 25 mM | 0.2577 mL | 1.2887 mL | 2.5775 mL | 6.4437 mL | |
| 30 mM | 0.2148 mL | 1.0740 mL | 2.1479 mL | 5.3698 mL | |
| 40 mM | 0.1611 mL | 0.8055 mL | 1.6109 mL | 4.0273 mL | |
| 50 mM | 0.1289 mL | 0.6444 mL | 1.2887 mL | 3.2219 mL | |
| 60 mM | 0.1074 mL | 0.5370 mL | 1.0740 mL | 2.6849 mL | |
| 80 mM | 0.0805 mL | 0.4027 mL | 0.8055 mL | 2.0137 mL | |
| 100 mM | 0.0644 mL | 0.3222 mL | 0.6444 mL | 1.6109 mL |
Bemegride 関連分類
HY-B1326 関連分類
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