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CH-223191

(別名: 301326-22-7)
120 Cited Publications
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Based on 120 publication(s) in Google Scholar

CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM.

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  • 純度: 99.82%
  • CAS 番号: 301326-22-7
  • 分子式: C19H19N5O
  • 分子量:333.39
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years

    * The compound is unstable in solutions, freshly prepared is recommended.

  • CH-223191 Chemical Structure
    CH-223191 構造式
  • Experimental Validation Results for CH-223191
  • Experimental Validation Results for CH-223191
  • Experimental Validation Results for CH-223191
  • Experimental Validation Results for CH-223191
  • Experimental Validation Results for CH-223191
  • Experimental Validation Results for CH-223191
CAS 番号: 301326-22-7
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  • CH-223191 Chemical Structure
    CH-223191 Chemical Structure
    1/16
  • 1/16

    CH-223191 purchased from MedChemExpress. Usage Cited in: Nat Metab. 2023 Feb;5(2):331-348. [Abstract]

    Customer Validation
     CH223191 suppresses GSK3β and Akt phosphorylation in chow-fed mice.

  • 1/16

    CH-223191 purchased from MedChemExpress. Usage Cited in: Chemosphere. 2019 Feb:216:372-378. [Abstract]

    Customer Validation
     AhR mediates EOM-inhibited cardiac differentiation by downregulating β-catenin expression in P19 cells. mRNA expression changes of β-catenin by Q-PCR. The concentrations of CH (CH223191, AhR antagonist) and CHIR (CHIR99021, Wnt activator) are 0.25 and 0.5 μM respectively.

  • 1/16

    CH-223191 purchased from MedChemExpress. Usage Cited in: Chemosphere. 2019 Feb:216:372-378. [Abstract]

    Customer Validation
     AhR mediates EOM-inhibited cardiac differentiation by downregulating β-catenin expression in P19 cells. Percentage of cTnT positive cells at differentiation day 14. The concentrations of CH (CH223191, AhR antagonist) and CHIR (CHIR99021, Wnt activator) are 0.25 and 0.5 μM respectively.

  • 1/16

    CH-223191 purchased from MedChemExpress. Usage Cited in: Chemosphere. 2019 Feb:216:372-378. [Abstract]

    Customer Validation
     AhR mediates EOM-inhibited cardiac differentiation by downregulating β-catenin expression in P19 cells. Percentage of cTnT positive cells at differentiation day 14. The concentrations of CH (CH223191, AhR antagonist) and CHIR (CHIR99021, Wnt activator) are 0.25 and 0.5 μM respectively.

  • 1/16

    CH-223191 purchased from MedChemExpress. Usage Cited in: Chemosphere. 2019 Feb:216:372-378. [Abstract]

    Customer Validation
     Proliferation of P19 cells exposed to EOM in the presence or absence of CH. Represent images of EdU staining (red) and the quantification results.

  • 1/16

    CH-223191 purchased from MedChemExpress. Usage Cited in: Toxicology. 2016 Apr 29:355-356:31-8. [Abstract]

    Customer Validation
     Western analysis of β-catenin protein level in zebrafish embryos exposed to EOM in the presence or absence of CH/CHIR (n = 3). Different letters indicate significant differences. Moreover, both CH and CHIR attenuate the EOM-induced changes in the protein level of b-catenin and in EROD activity.

  • CH-223191