ML347
Based on 10 publication(s) in Google Scholar
ML347 (LDN193719) is a highly selective ALK1/ALK2 inhibitor. ML347 has IC50 values of 46 and 32 nM against ALK1 and ALK2, respectively, >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-β1.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.94%
- CAS 番号: 1062368-49-3
- 分子式: C22H16N4O
- 分子量:352.39
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 ML347
More- Bone Res. 2024 Sep 4;12(1):50. [Abstract]
- J Cell Mol Med. 2024 Nov;28(22):e70214. [Abstract]
- Biomedicines. 2026 Jan 28;14(2):288. [Abstract]
- J Leukoc Biol. 2023 Nov 24;114(6):639-650. [Abstract]
- Oncologie. 2025 Mar 4.
- J Mol Histol. 2021 Feb;52(1):77-86. [Abstract]
- SSRN. 2025 Jul 25.
- Patent. US20220002732A1.
- J Bioma Ter Tiss Eng. 2020 Jun.
- Patent. US20170369886A1.
Customer Validation & Images
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WB
生物活性
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ALK1 46 nM (IC50) |
ACVR1 32 nM (IC50) |
BMPR1A 10800 nM (IC50) |
ML347 can inhibit ALK1/ALK2 to block TGF?β signal transduction[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary dental epithelial cells were cultured in Dulbecco’s Modifed Eagle Medium (DMEM)/ F12 supplemented with 20% fetal bovine serum and 1% penicillin/streptomycin.
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Concentration:25 μM
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Incubation Time:2 hours
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Result:Inhibited ALK1/ALK2 then blocking Smad1/5 by TGF-β1.
化学情報
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CAS 番号 1062368-49-3
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性状 Solid
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分子量 352.39
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分子式 C22H16N4O
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Color Light yellow to yellow
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SMILES
COC1=CC=C(C2=CN3C(N=C2)=C(C4=C5C=CC=NC5=CC=C4)C=N3)C=C1
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別名
LDN 193719
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (10)
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Journal Impact Factor
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Most Recent
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Bone Res
Targeting Fascin1 maintains chondrocytes phenotype and attenuates osteoarthritis development. [Abstract]2024 Sep 4;12(1):50. PMID: 39231936 -
J Cell Mol Med
Sinomenine Ameliorated Microglial Activation and Neuropathic Pain After Chronic Constriction Injury Via TGF-β1/ALK5/Smad3 Signalling Pathway. [Abstract]2024 Nov;28(22):e70214. PMID: 39586784 -
Biomedicines
2026 Jan 28;14(2):288. PMID: 41751187 -
J Leukoc Biol
Non-functional TGF-β/ALK1/ENG Signaling Pathway supports neutrophil pro-angiogenic activity in Hereditary Hemorrhagic Telangiectasia. [Abstract]2023 Nov 24;114(6):639-650. PMID: 37555392 -
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J Mol Histol
2021 Feb;52(1):77-86. PMID: 33206256 -
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ML347 purchased from MedChemExpress. Usage Cited in: Patent. US20170369886A1.
FIG illustrates angiogenesis in the absence and presence of an Alk1 small molecule inhibitor (ML347) in presence or absence of inhibin α.
溶剤 & 溶解度
DMSO : 10 mg/mL (28.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (279 KB)
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SDS (761 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Engers DW, et al. Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52. [Content Brief]
[2]. Zhang H, et al. Dual roles of TGF-β signaling in the regulation of dental epithelial cell proliferation. J Mol Histol. 2021 Feb;52(1):77-86. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.8378 mL | 14.1888 mL | 28.3776 mL | 70.9441 mL |
| 5 mM | 0.5676 mL | 2.8378 mL | 5.6755 mL | 14.1888 mL | |
| 10 mM | 0.2838 mL | 1.4189 mL | 2.8378 mL | 7.0944 mL | |
| 15 mM | 0.1892 mL | 0.9459 mL | 1.8918 mL | 4.7296 mL | |
| 20 mM | 0.1419 mL | 0.7094 mL | 1.4189 mL | 3.5472 mL | |
| 25 mM | 0.1135 mL | 0.5676 mL | 1.1351 mL | 2.8378 mL |
ML347 関連分類
HY-12274 関連分類
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