メサコニチン
Based on 2 publication(s) in Google Scholar
Mesaconitine is a nitric oxide synthase activator. Mesaconitine drives extracellular Na+ and Ca2+ influx into endothelial cells, increases intracellular Na+ and Ca2+ concentrations, and triggers nitric oxide release. Mesaconitine is applicable for pain-related research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.19%
- CAS 番号: 2752-64-9
- 分子式: C33H45NO11
- 分子量:631.71
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 Mesaconitine
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
>20 μM
Compound: 8
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Antiproliferative activity against human A549 cells by sulforhodamine B assay
Antiproliferative activity against human A549 cells by sulforhodamine B assay
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[PMID: 25770782] |
| DU-145 | GI50 |
>20 μM
Compound: 8
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Antiproliferative activity against human DU145 cells by sulforhodamine B assay
Antiproliferative activity against human DU145 cells by sulforhodamine B assay
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[PMID: 25770782] |
| KB | GI50 |
>20 μM
Compound: 8
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Antiproliferative activity against human KB cells by sulforhodamine B assay
Antiproliferative activity against human KB cells by sulforhodamine B assay
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[PMID: 25770782] |
Mesaconitine (30 μM) induces a sustained increase in [Ca2+]ᵢ in HUVECs with a net increase of 361 nM in normal buffer, which is dependent on extracellular Ca2+ and Na+, inhibited by the reverse-mode Na+/Ca2+ exchanger inhibitor KBR7943 and the nicotinic acetylcholine receptor inhibitor D-tubocurarine, and unaffected by the Na+/H+ exchanger inhibitor Cimetidine (HY-14289)[2].
Mesaconitine (100 μM) induces a small increase in [Na+]i in HUVECs, which is inhibited by the nicotinic acetylcholine receptor inhibitor D-tubocurarine[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Mesaconitine (11 μg/kg; s.c.; single dose) produces dose-dependent central analgesia in the tail flick model with an ED50 of 11 μg/kg[3].
Mesaconitine (60 μg/kg; s.c.; single dose) modulates central catecholamine levels and turnover in rats, specifically accelerating norepinephrine depletion in select brain and spinal cord regions and dopamine depletion in the striatum when combined with α-methyl-p-tyrosine[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Std:ddY (male, 20-24 g)[3]
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Dosage:20 μg/kg; 60 μg/kg
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Administration:s.c.; single dose
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Result:Exhibited dose-dependent analgesic activity with an ED50 of 28 μg/kg.
Reached maximum analgesic activity 40 minutes after s.c.
administration, with significant activity persisting for 4 hours at 20 μg/kg and 7 hours at 60 μg/kg.
Showed significantly reduced analgesia when co-administered with α-methyl-p-tyrosine, 6-hydroxydopamine, diethyldithiocarbamate, disulfiram, or reserpine.
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Animal Model:Wistar (male, 200-220 g)[3]
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Dosage:60 μg/kg
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Administration:s.c.; single dose
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Result:Increased dopamine levels in the diencephalon, and norepinephrine and 5-hydroxytryptamine levels in the mesencephalon.
Accelerated the α-methyl-p-tyrosine-induced reduction of norepinephrine levels in the hippocampus, medulla oblongata plus pons, and spinal cord, and of dopamine levels in the striatum.
化学情報
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CAS 番号 2752-64-9
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性状 Solid
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分子量 631.71
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分子式 C33H45NO11
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Color White to off-white
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SMILES
CO[C@@H]1C2([C@@](C[C@@]3(O)[C@@H]4OC(C5=CC=CC=C5)=O)([H])[C@@]4([H])[C@](OC(C)=O)([C@@H](O)[C@@H]3OC)C6C2N(C)C7)[C@@]([C@H]6OC)([H])[C@@]7(COC)[C@H](O)C1
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別名
Mesaconitine
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (2)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
Ethanol : 4.62 mg/mL (7.31 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (292 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Mitamura M,ei al. Mesaconitine-induced relaxation in rat aorta: involvement of Ca2+ influx and nitric-oxide synthase in the endothelium. Eur J Pharmacol. 2002 Feb 2;436(3):217-25. [Content Brief]
[2]. Ogura J, et al. Mesaconitine-induced relaxation in rat aorta: role of Na+/Ca2+ exchangers in endothelial cells. Eur J Pharmacol. 2004;483(2-3):139-146. [Content Brief]
[3]. Murayama M, et al. Mechanism of analgesic action of mesaconitine. I. Relationship between analgesic effect and central monoamines or opiate receptors. Eur J Pharmacol. 1984;101(1-2):29-36. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 1.5830 mL | 7.9150 mL | 15.8300 mL | 39.5751 mL |
| 5 mM | 0.3166 mL | 1.5830 mL | 3.1660 mL | 7.9150 mL |
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