NS-638
Based on 1 Customer Validation
NS-638 is a small nonpeptide molecule with Ca2+-channel blocking properties. K+-stimulated intracellular Ca2+-elevation is blocked with an IC50 value of 3.4 μM.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.84%
- CAS 番号: 150493-34-8
- 分子式: C15H11ClF3N3
- 分子量:325.72
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
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- 純度とドキュメンテーション
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Calcium Channel アイソフォーム固有の製品をすべて表示
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生物活性
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L-type calcium channel |
NS-638 dose dependently inhibits K+-stimulated [45 Ca2+]-uptake in chick cortical synaptosomes and 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA)- stimulated [3H]GABA-release from cultured cortical neurons with IC50 values of 2.3 and 4.3 μM, respectively. K+-stimulated intracellular Ca2+-elevation in cultured cerebellar granule cells is equipotently blocked with an IC50 value of 3.4 μM. At this concentration no effect on Ca2+-induced contractions in K+-depolarized guinea pig taenia coli is observed. NS-638 reversibly blocks N- and L-type Ca2+-channels in cultured chick dorsal root ganglion cells in the concentration range of 1-30 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 150493-34-8
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性状 Solid
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分子量 325.72
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分子式 C15H11ClF3N3
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Color White to off-white
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SMILES
NC1=NC2=CC(C(F)(F)F)=CC=C2N1CC3=CC=C(Cl)C=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
DMSO : ≥ 34 mg/mL (104.38 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
プロトコル
The effect of NS-638 on neuronal Ca2+-channels is evaluated using whole cell patch clamp techniques[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Mice: In the mouse middle cerebral artery occlusion model, NS-638 is administered i.p. (50 mg kg-1) at 1 h and 6 h post-ischemia, and once a day for the next two days[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
純度とドキュメンテーション
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データシート (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0701 mL | 15.3506 mL | 30.7012 mL | 76.7530 mL |
| 5 mM | 0.6140 mL | 3.0701 mL | 6.1402 mL | 15.3506 mL | |
| 10 mM | 0.3070 mL | 1.5351 mL | 3.0701 mL | 7.6753 mL | |
| 15 mM | 0.2047 mL | 1.0234 mL | 2.0467 mL | 5.1169 mL | |
| 20 mM | 0.1535 mL | 0.7675 mL | 1.5351 mL | 3.8377 mL | |
| 25 mM | 0.1228 mL | 0.6140 mL | 1.2280 mL | 3.0701 mL | |
| 30 mM | 0.1023 mL | 0.5117 mL | 1.0234 mL | 2.5584 mL | |
| 40 mM | 0.0768 mL | 0.3838 mL | 0.7675 mL | 1.9188 mL | |
| 50 mM | 0.0614 mL | 0.3070 mL | 0.6140 mL | 1.5351 mL | |
| 60 mM | 0.0512 mL | 0.2558 mL | 0.5117 mL | 1.2792 mL | |
| 80 mM | 0.0384 mL | 0.1919 mL | 0.3838 mL | 0.9594 mL | |
| 100 mM | 0.0307 mL | 0.1535 mL | 0.3070 mL | 0.7675 mL |
NS-638 関連分類
HY-101428 関連分類
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