Neurokinin A
Based on 3 publication(s) in Google Scholar
Neurokinin A (Substance K), a peptide neurotransmitter of the tachykinin family, acts via the NK-2 receptor. Neurokinin A acts as a major mediator in human airway and gastrointestinal tissues.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.61%
- CAS 番号: 86933-74-6
- 分子式: C50H80N14O14S
- 分子量:1133.32
-
保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
![[Sar9,Met(O2)11]-Substance P](https://file.medchemexpress.com/product_pic/hy-p1012.gif)
MedChemExpress（MCE）の使用を引用している文献 Neurokinin A
More
Customer Validation & Images
-
Flow Cytometry
生物活性
製品説明
IC50 & Target
NK-2 receptor[1]
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
53 nM
Compound: Neurokinin-A
|
Compound was evaluated for concentration-dependent and oscillatory increase in [Ca2+], caused by activation of hNK3 receptors in CHO cells
Compound was evaluated for concentration-dependent and oscillatory increase in [Ca2+], caused by activation of hNK3 receptors in CHO cells
|
[PMID: 9871763] |
| HEK293 | EC50 |
0.55 nM
Compound: NKA
|
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as increase in intracellular calcium level by spectrofluorimetry
|
[PMID: 19746979] |
| HEK293 | EC50 |
64.8 nM
Compound: NKA
|
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay
Allosteric modulation of rat NK2 receptor expressed in HEK293 cells assessed as cAMP production by radioimmunoassay
|
[PMID: 19746979] |
体外実験
Neurokinin A (substance K) is a peptide neurotransmitter of the tachykinin family with potential as a major mediator in human airway and gastrointestinal tissues. Neurokinin A acts via the NK-2 receptor believed to be localized on smooth muscle cells and pharmacologically coupled to a GTP-binding protein. Neurokinin A is a member of a family of peptide neurotransmitters known as tachykinins. These peptides are associated with the central and peripheral nervous systems and display a wide tissue distribution. Tachykinins share the COOH-terminal structure Phe-X-Gly-Leu-Met-NH. The best known members of this family are Substance P and Neurokinin A or Substance K[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 86933-74-6
-
性状 Solid
-
分子量 1133.32
-
分子式 C50H80N14O14S
-
Color White to off-white
-
別名
ニューロキニンA; Substance K; Neurokinin α; Neuromedin L
-
配列
His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met-NH2
-
シーケンスの短縮
HKTDSFVGLM-NH2
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
-
Journal Impact Factor
-
Most Recent
-
Life Sci
TRPM3 channel activation inhibits contraction of the isolated human ureter via CGRP released from sensory nerves. [Abstract]2021 Mar 1:268:118967. PMID: 33417951 -
Scand J Immunol
Substance P and neurokinin 1 receptor boost the pathogenicity of granulocyte-macrophage colony-stimulating factor-producing T helper cells in dry eye disease. [Abstract]2025 Jan;101(1):e13434. PMID: 39789752
Neurokinin A purchased from MedChemExpress. Usage Cited in: Scand J Immunol. 2025 Jan;101(1):e13434. [Abstract]
Neurokinin A (NKA, 10 nM-1 μM; 5 days). Frequencies of IFN-γ+ and GM-CSF+ cells after the culture.
-
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (88.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 5 mg/mL (4.41 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (270 KB)
-
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 0.8824 mL | 4.4118 mL | 8.8236 mL | 22.0591 mL |
| DMSO | 5 mM | 0.1765 mL | 0.8824 mL | 1.7647 mL | 4.4118 mL |
| 10 mM | 0.0882 mL | 0.4412 mL | 0.8824 mL | 2.2059 mL | |
| 15 mM | 0.0588 mL | 0.2941 mL | 0.5882 mL | 1.4706 mL | |
| 20 mM | 0.0441 mL | 0.2206 mL | 0.4412 mL | 1.1030 mL | |
| 25 mM | 0.0353 mL | 0.1765 mL | 0.3529 mL | 0.8824 mL | |
| 30 mM | 0.0294 mL | 0.1471 mL | 0.2941 mL | 0.7353 mL | |
| 40 mM | 0.0221 mL | 0.1103 mL | 0.2206 mL | 0.5515 mL | |
| 50 mM | 0.0176 mL | 0.0882 mL | 0.1765 mL | 0.4412 mL | |
| 60 mM | 0.0147 mL | 0.0735 mL | 0.1471 mL | 0.3677 mL | |
| 80 mM | 0.0110 mL | 0.0551 mL | 0.1103 mL | 0.2757 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Neurokinin A 関連分類
HY-P0197 関連分類
Powered by Bioz