Octopamine (hydrochloride)
Based on 5 publication(s) in Google Scholar
Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure.
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- 純度: 99.90%
- CAS 番号: 770-05-8
- 分子式: C8H12ClNO2
- 分子量:189.64
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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MedChemExpress（MCE）の使用を引用している文献 Octopamine hydrochloride
MoreAdrenergic Receptor アイソフォーム固有の製品をすべて表示
MoreEndogenous Metabolite アイソフォーム固有の製品をすべて表示
More
生物活性
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Human Endogenous Metabolite |
α2-adrenergic receptor |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
978 nM
Compound: OA
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Agonist activity at Chilo suppressalis (rice stem borer) tyramine receptor TyR1 expressed in HEK293 cells assessed as reduction in forskolin-induced cAMP accumulation incubated for 20 min
Agonist activity at Chilo suppressalis (rice stem borer) tyramine receptor TyR1 expressed in HEK293 cells assessed as reduction in forskolin-induced cAMP accumulation incubated for 20 min
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[PMID: 23129510] |
Octopamine has a prominent role in influencing multiple physiological events: (a) as a neuromodulator, it regulates desensitization of sensory inputs, arousal, initiation, and maintenance of various rhythmic behaviors and complex behaviors such as learning and memory; (b) as a neurotransmitter, it regulates endocrine gland activity; and (c) as a neurohormone, it induces mobilization of lipids and carbohydrates. Octopamine exerts its effects by binding to specific proteins that belong to the superfamily of G protein-coupled receptors and share the structural motif of seven transmembrane domains[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 770-05-8
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性状 Solid
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分子量 189.64
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分子式 C8H12ClNO2
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Color White to off-white
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SMILES
OC(C1=CC=C(O)C=C1)CN.Cl
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別名
(±)-p-Octopamine (hydrochloride); オクトパミン塩酸塩
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (5)
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Journal Impact Factor
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Most Recent
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Cell Res
Light sensing enhances thermotolerance and competitive fitness via serotonergic signaling in an eyeless organism. [Abstract]2026 Apr;36(4):286-299. PMID: 41764323 -
Nat Commun
2025 Dec 18;16(1):11196. PMID: 41413037 -
Insect Mol Biol
2022 Oct;31(5):647-658. PMID: 35652818 -
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溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (527.31 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : ≥ 50 mg/mL (263.66 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (527.31 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
[1]. Roeder T. Octopamine in invertebrates. Prog Neurobiol. 1999;59(5):533-561. [Content Brief]
[2]. Farooqui T. Octopamine-mediated neuromodulation of insect senses. Neurochem Res. 2007;32(9):1511-1529. [Content Brief]
[3]. Axelrod J, et al. Octopamine. Nature. 1977;265(5594):501-504. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 5.2731 mL | 26.3657 mL | 52.7315 mL | 131.8287 mL |
| 5 mM | 1.0546 mL | 5.2731 mL | 10.5463 mL | 26.3657 mL | |
| 10 mM | 0.5273 mL | 2.6366 mL | 5.2731 mL | 13.1829 mL | |
| 15 mM | 0.3515 mL | 1.7577 mL | 3.5154 mL | 8.7886 mL | |
| 20 mM | 0.2637 mL | 1.3183 mL | 2.6366 mL | 6.5914 mL | |
| 25 mM | 0.2109 mL | 1.0546 mL | 2.1093 mL | 5.2731 mL | |
| 30 mM | 0.1758 mL | 0.8789 mL | 1.7577 mL | 4.3943 mL | |
| 40 mM | 0.1318 mL | 0.6591 mL | 1.3183 mL | 3.2957 mL | |
| 50 mM | 0.1055 mL | 0.5273 mL | 1.0546 mL | 2.6366 mL | |
| 60 mM | 0.0879 mL | 0.4394 mL | 0.8789 mL | 2.1971 mL | |
| 80 mM | 0.0659 mL | 0.3296 mL | 0.6591 mL | 1.6479 mL | |
| 100 mM | 0.0527 mL | 0.2637 mL | 0.5273 mL | 1.3183 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Octopamine hydrochloride 関連分類
HY-B0528A 関連分類
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