RI-2
Based on 1 publication(s) in Google Scholar
RI-2 is a reversible RAD51 inhibitor, with an IC50 of 44.17 μM, and specifically inhibits homologous recombination repair in human cells.
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- 純度 : 99.90%
- CAS 番号: 1417162-36-7
- 分子式: C21H18Cl2N2O4
- 分子量:433.28
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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生物活性
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化学情報
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溶剤 & 溶解度
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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MedChemExpress（MCE）の使用を引用している文献 RI-2
More
生物活性
製品説明
IC50 & Target
IC50: 44.17 μM (RAD51)[1]
体外実験
RI-2 (7a) is a reversible RAD51 inhibitor, with an IC50 of 44.17 μM. RI-2 specifically inhibits homologous recombination repair in human cells. RI-2 (150 μM) induces a significant sensitization of cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1417162-36-7
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性状 Solid
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分子量 433.28
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分子式 C21H18Cl2N2O4
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Color Yellow to orange
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SMILES
O=C(C(C1=CC=C(OC)C=C1)=C2N3CCOCC3)N(C4=CC=C(Cl)C(Cl)=C4)C2=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
溶剤 & 溶解度
体外:
DMSO : 130 mg/mL (300.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3080 mL | 11.5399 mL | 23.0798 mL | 57.6994 mL |
| 5 mM | 0.4616 mL | 2.3080 mL | 4.6160 mL | 11.5399 mL | |
| 10 mM | 0.2308 mL | 1.1540 mL | 2.3080 mL | 5.7699 mL | |
| 15 mM | 0.1539 mL | 0.7693 mL | 1.5387 mL | 3.8466 mL | |
| 20 mM | 0.1154 mL | 0.5770 mL | 1.1540 mL | 2.8850 mL | |
| 25 mM | 0.0923 mL | 0.4616 mL | 0.9232 mL | 2.3080 mL | |
| 30 mM | 0.0769 mL | 0.3847 mL | 0.7693 mL | 1.9233 mL | |
| 40 mM | 0.0577 mL | 0.2885 mL | 0.5770 mL | 1.4425 mL | |
| 50 mM | 0.0462 mL | 0.2308 mL | 0.4616 mL | 1.1540 mL | |
| 60 mM | 0.0385 mL | 0.1923 mL | 0.3847 mL | 0.9617 mL | |
| 80 mM | 0.0288 mL | 0.1442 mL | 0.2885 mL | 0.7212 mL | |
| 100 mM | 0.0231 mL | 0.1154 mL | 0.2308 mL | 0.5770 mL |
RI-2 関連分類
HY-16904 関連分類
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