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製品番号: HY-102016

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SB756050

2 Cited Publications

カスタマーレビュー

Based on 2 publication(s) in Google Scholar

SB756050 is a selective TGR5 agonist. SB756050 has the potential for type 2 diabetes treatment.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.75%
CAS 番号: 447410-57-3
分子式: C₂₁H₂₈N₂O₈S₂
分子量:500.59

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

SB756050 構造式

CAS 番号: 447410-57-3

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

SB756050 is a selective TGR5 agonist. SB756050 has the potential for type 2 diabetes treatment.

体外実験

TGR5 is a bile acid receptor and a potential target for the treatment of type 2 diabetes (T2D)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

SB756050 is well‐tolerated; it is readily absorbed, exhibited nonlinear pharmacokinetics with a less than dose‐proportional increase in plasma exposure above 100 mg, and demonstrates no significant changes in exposure when co‐administered with sitagliptin. SB756050 demonstrates highly variable pharmacodynamic effects both within dose groups and between doses, with increases in glucose seen at the two lowest doses and no reduction in glucose seen at the two highest doses. The glucose effects of SB756050 sitagliptin are comparable to those of sitagliptin alone, even though gut hormone plasma profiles are different^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 447410-57-3
性状 Solid
分子量 500.59
分子式 C₂₁H₂₈N₂O₈S₂
Color White to off-white
SMILES

O=S(N1CCN(S(=O)(C2=CC=C(OC)C(OC)=C2)=O)CCC1)(C3=CC=C(OC)C(OC)=C3)=O
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (2)

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Cell Death Discov

TGR5-HNF4α axis contributes to bile acid-induced gastric intestinal metaplasia markers expression. [Abstract]

2020 Jul 6:6:56. PMID: 32655894

SB756050 purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2020 Jul 6:6:56. [Abstract]

GES-1 cells are treated with SB756050 (2, 5, and 10 μM) for 24 h. KLF4 and CDX2 protein expression is examined by WB. The results show that KLF4 and CDX2 expression is significantly increased.
R Soc Open Sci

Ultra-performance liquid chromatography-tandem mass spectrometric method for quantitation of the recently Food and Drug Administration approved combination of vaborbactam and meropenem in human plasma. [Abstract]

2020 Jul 8;7(7):200635. PMID: 32874656

溶剤 & 溶解度

体外:

DMSO : 50 mg/mL (99.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.9976 mL

9.9882 mL

19.9764 mL

5 mM

0.3995 mL

1.9976 mL

3.9953 mL

10 mM

0.1998 mL

0.9988 mL

1.9976 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Hodge RJ, et al. Safety, Pharmacokinetics, and Pharmacodynamic Effects of a Selective TGR5 Agonist, SB-756050, in Type 2 Diabetes. Clin Pharmacol Drug Dev. 2013 Jul;2(3):213-22. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.9976 mL	9.9882 mL	19.9764 mL	49.9411 mL
	5 mM	0.3995 mL	1.9976 mL	3.9953 mL	9.9882 mL
	10 mM	0.1998 mL	0.9988 mL	1.9976 mL	4.9941 mL
	15 mM	0.1332 mL	0.6659 mL	1.3318 mL	3.3294 mL
	20 mM	0.0999 mL	0.4994 mL	0.9988 mL	2.4971 mL
	25 mM	0.0799 mL	0.3995 mL	0.7991 mL	1.9976 mL
	30 mM	0.0666 mL	0.3329 mL	0.6659 mL	1.6647 mL
	40 mM	0.0499 mL	0.2497 mL	0.4994 mL	1.2485 mL
	50 mM	0.0400 mL	0.1998 mL	0.3995 mL	0.9988 mL
	60 mM	0.0333 mL	0.1665 mL	0.3329 mL	0.8324 mL
	80 mM	0.0250 mL	0.1249 mL	0.2497 mL	0.6243 mL

Keywords

SB756050

2 Cited Publications

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SB756050 purchased from MedChemExpress. Usage Cited in: Cell Death Discov. 2020 Jul 6:6:56. [Abstract]

Customer Validation
GES-1 cells are treated with SB756050 (2, 5, and 10 μM) for 24 h. KLF4 and CDX2 protein expression is examined by WB. The results show that KLF4 and CDX2 expression is significantly increased.

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SB756050

Anti-diabetic Compound Library

Orally Active Compound Library

Anti-Obesity Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Activators Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

GPCR/G Protein Compound Library

Clinical Compound Library

MedChemExpress（MCE）の使用を引用している文献 SB756050

生物活性

化学情報

Publications (2)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

SB756050

Anti-diabetic Compound Library

Orally Active Compound Library

Anti-Obesity Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Highly Selective Activators Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

Lactylation Compound Library

GPCR/G Protein Compound Library

Clinical Compound Library

MedChemExpress（MCE）の使用を引用している文献 SB756050

生物活性

化学情報

Publications (2)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

SB756050 関連分類

HY-102016 関連分類