SL 0101-1
Based on 8 publication(s) in Google Scholar
SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM. SL 0101-1 (SL0101) is a selective RSK1/2 inhibitor, with a Ki of 1 μM.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.0%
- CAS 番号: 77307-50-7
- 分子式: C25H24O12
- 分子量:516.45
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 SL 0101-1
More- Mol Cell. 2020 Oct 15;80(2):296-310.e6. [Abstract]
- PLoS Biol. 2022 Jun 1;20(6):e3001653. [Abstract]
- JCI Insight. 2025 Jul 8;10(13):e187684. [Abstract]
- Int J Mol Sci. 2023 Oct 3;24(19):14854. [Abstract]
- PLoS Pathog. 2025 Nov 24;21(11):e1013737. [Abstract]
- iScience. 2024 Dec 15;28(1):111603. [Abstract]
- J Proteome Res. 2025 Oct 28. [Abstract]
- Mol Biol Cell. 2022 Oct 1;33(12):ar115. [Abstract]
生物活性
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RSK1 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCC70 | IC50 |
15 μM
Compound: 52; SL0101
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Anticancer activity against human HCC70 cells assessed as cell growth inhibition incubated up to 72 hrs by Cell-Titre Glo assay
Anticancer activity against human HCC70 cells assessed as cell growth inhibition incubated up to 72 hrs by Cell-Titre Glo assay
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[PMID: 33650861] |
| MCF7 | IC50 |
45.6 μM
Compound: 1, SL0101
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Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter-GloTM assay
Antiproliferative activity against human MCF7 cells after 48 hrs by CellTiter-GloTM assay
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[PMID: 22464132] |
| MDA-MB-231 | IC50 |
3 μM
Compound: 52; SL0101
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Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated up to 72 hrs by Cell-Titre Glo assay
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition incubated up to 72 hrs by Cell-Titre Glo assay
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[PMID: 33650861] |
| Sf9 | IC50 |
0.583 μM
Compound: 1, SL0101
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Inhibition of His-tagged RSK2 expressed in Sf9 cells using ERalpha-Ser167 RLASTND as substrate after 120 mins by chemiluminescence assay
Inhibition of His-tagged RSK2 expressed in Sf9 cells using ERalpha-Ser167 RLASTND as substrate after 120 mins by chemiluminescence assay
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[PMID: 22464132] |
| Sf9 | IC50 |
0.99 μM
Compound: 1, SL0101
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Inhibition of recombinant RSK2 (unknown origin) expressed in baculovirus infected Sf9 cells assessed as decrease in substrate phosphorylation using GST-fusion protein containing ERalpha-Ser167 sequence-RLASTND as substrate by chemiluminescence analysis
Inhibition of recombinant RSK2 (unknown origin) expressed in baculovirus infected Sf9 cells assessed as decrease in substrate phosphorylation using GST-fusion protein containing ERalpha-Ser167 sequence-RLASTND as substrate by chemiluminescence analysis
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[PMID: 23519677] |
| Sf9 | IC50 |
89 nM
Compound: SL0101
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Inhibition of his-tagged active RSK2 (unknown origin) expressed in Sf9 cells after 10 to 45 mins by ELISA
Inhibition of his-tagged active RSK2 (unknown origin) expressed in Sf9 cells after 10 to 45 mins by ELISA
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[PMID: 25147152] |
化学情報
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CAS 番号 77307-50-7
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性状 Solid
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分子量 516.45
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分子式 C25H24O12
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Color White to yellow
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SMILES
OC1=CC(O)=C(C(C(O[C@@H]2O[C@@H](C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]2O)=C(C3=CC=C(O)C=C3)O4)=O)C4=C1
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別名
SL0101
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (8)
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Journal Impact Factor
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Most Recent
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Mol Cell
2020 Oct 15;80(2):296-310.e6. PMID: 32979304 -
PLoS Biol
RSK1 promotes mammalian axon regeneration by inducing the synthesis of regeneration-related proteins. [Abstract]2022 Jun 1;20(6):e3001653. PMID: 35648763 -
JCI Insight
Glycoprotein NMB mediates bidirectional GSC-TAM interactions to promote tumor progression. [Abstract]2025 Jul 8;10(13):e187684. PMID: 40626360 -
Int J Mol Sci
Phosphorylation-Assisted Luciferase Complementation Assay Designed to Monitor Kinase Activity and Kinase-Domain-Mediated Protein-Protein Binding. [Abstract]2023 Oct 3;24(19):14854. PMID: 37834301 -
PLoS Pathog
ORF45-induced Filamin A phosphorylation promotes cell motility and cell-contact dependent viral infection of Kaposi's sarcoma-associated herpesvirus. [Abstract]2025 Nov 24;21(11):e1013737. PMID: 41284726 -
iScience
2024 Dec 15;28(1):111603. PMID: 39834856 -
J Proteome Res
RSK Inhibition Rewires Kinase Networks and Triggers Cascading Pathway Disruption in Esophageal Cancer. [Abstract]2025 Oct 28. PMID: 41157826 -
Mol Biol Cell
Revisiting the multisite phosphorylation that produces the M-phase supershift of key mitotic regulators. [Abstract]2022 Oct 1;33(12):ar115. PMID: 35976701
溶剤 & 溶解度
DMSO : 10 mg/mL (19.36 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Smith JA, et al. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 2005 Feb 1;65(3):1027-34. [Content Brief]
[2]. Yu Li, et al. The Affinity of RSK for Cylitol Analogues of SL0101 Is Critically Dependent on the B-ring C-4'-hydroxy. Chem Commun (Camb). 2020 Mar 10;56(20):3058-3060. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9363 mL | 9.6815 mL | 19.3630 mL | 48.4074 mL |
| 5 mM | 0.3873 mL | 1.9363 mL | 3.8726 mL | 9.6815 mL | |
| 10 mM | 0.1936 mL | 0.9681 mL | 1.9363 mL | 4.8407 mL | |
| 15 mM | 0.1291 mL | 0.6454 mL | 1.2909 mL | 3.2272 mL |
SL 0101-1 関連分類
HY-15237 関連分類
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